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更新于：2026-08-29
Mitoxantrone Hydrochloride liposomal
盐酸米托蒽醌脂质体
更新于：2026-08-29
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 中国 (2021-06-01), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国)、附条件批准 (中国) |
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结构/序列
分子式C22H30Cl2N4O6 |
InChIKeyZAHQPTJLOCWVPG-UHFFFAOYSA-N |
CAS号70476-82-3 |
关联
140
项与 盐酸米托蒽醌脂质体 相关的临床试验NCT07725705
An Open-label, Multicenter, Phase Ib/II Exploratory Clinical Study of EZH2 Inhibitor SHR2554 in Combination With Liposomal Mitoxantrone for the First-line Treatment of Peripheral T-cell Lymphoma
This is a single-arm, multicenter, Phase Ib/IIa study designed to explore the efficacy and safety of SHR2554 in combination with liposomal mitoxantrone for the treatment of patients with treatment-naive peripheral T-cell lymphoma (PTCL). The study is divided into a Phase Ib safety lead-in phase and a Phase IIa dose expansion phase.
开始日期2026-08-01 |
申办/合作机构 |
NCT07735117
A Prospective, Multicenter, Randomized Controlled Clinical Study of Mitoxantrone Hydrochloride Liposome, Subcutaneous Cytarabine and G-CSF Combined With Venetoclax Versus Azacitidine Combined With Venetoclax in the Treatment of MDS-IB2 and Newly Diagnosed Adult Secondary or Elderly AML
This study aims to evaluate the efficacy and safety of mitoxantrone hydrochloride liposome, subcutaneous cytarabine and G-CSF combined with venetoclax (CMG+Ven) versus azacitidine combined with venetoclax (VA) in the treatment of adult myelodysplastic syndrome IB2 (MDS-IB2) and newly diagnosed secondary or elderly AML.
开始日期2026-07-30 |
申办/合作机构  上海交通大学医学院附属瑞金医院 [+1] |
NCT07490288
A Single-Arm, Open-Label Study of Venetoclax, Azacitidine, and Liposomal Mitoxantrone (VAM) as Induction Therapy in Newly-diagnosed Adult Patients With Acute Myeloid Leukemia (AML)
This is a single-arm, open-label clinical trial evaluating the safety and preliminary efficacy of a novel induction regimen combining Venetoclax, Azacitidine, and Liposomal Mitoxantrone (VAM) in patients with newly diagnosed Acute Myeloid Leukemia (AML) who are eligible for intensive chemotherapy.
The study plans to enroll 27 participants. Patients will receive VAM induction therapy, followed by three cycles of intermediate-dose cytarabine consolidation. Allogeneic hematopoietic stem cell transplantation is recommended for high-risk or MRD-positive patients in remission.
The study plans to enroll 27 participants. Patients will receive VAM induction therapy, followed by three cycles of intermediate-dose cytarabine consolidation. Allogeneic hematopoietic stem cell transplantation is recommended for high-risk or MRD-positive patients in remission.
开始日期2026-05-08 |
申办/合作机构 |
100 项与 盐酸米托蒽醌脂质体 相关的临床结果
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100 项与 盐酸米托蒽醌脂质体 相关的转化医学
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100 项与 盐酸米托蒽醌脂质体 相关的专利（医药）
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4,709
项与 盐酸米托蒽醌脂质体 相关的文献（医药）2026-08-01·PEDIATRIC BLOOD & CANCER
Pharmacokinetics, Efficacy, and Safety Profiles of Mitoxantrone Hydrochloride Liposome Plus Cytarabine in Pediatric Patients With Newly Diagnosed Acute Myeloid Leukemia
Article
作者: Liu, Tianfeng ; Hu, Tianyuan ; Li, Tianyu ; Li, Xiaolan ; Zhu, Xiaofan ; Chen, Xiaojuan ; Zhang, Aoli ; Zhang, Yingchi ; Wang, Shuchun ; Zhang, Ranran ; Guo, Ye ; Liu, Lipeng ; Chen, Yumei ; Yang, Wenyu ; Qi, Benquan
ABSTRACT:
Background:
Mitoxantrone hydrochloride liposome (Lipo‐MIT), an innovative anthracycline nano‐drug, has demonstrated a favorable pharmacokinetics (PK) profile in lymphoma and preliminary efficacy in adult acute myeloid leukemia (AML). This study investigated the PK profile, efficacy, and safety of Lipo‐MIT plus cytarabine in newly diagnosed pediatric AML.
Methods:
In this single‐arm, open‐label trial, eligible patients received Lipo‐MIT and cytarabine every 4 weeks for two cycles. The primary endpoint was the PK characteristics of Lipo‐MIT after the first dose.
Results:
Between July 19, 2023, and November 14, 2023, eight pediatric patients were enrolled. The total and free mitoxantrone concentrations increased rapidly during the absorption phase and then declined gradually to minimal concentrations before the administration of the second dose. The mean elimination half‐life of total mitoxantrone was 60.2 ± 9.4 h, and the ratio of the area under the plasma concentration–time curve from Time 0 to the time of the last quantifiable concentration (AUC
0‐t
) of free mitoxantrone to total mitoxantrone was 1.8% ± 0.6%. The overall response rate and composite complete remission rate were both 85.7% (6/7). Measurable residual disease negativity was achieved in four (66.7%) patients after Cycle 1 and in six (100.0%) after Cycle 2. The 1‐year relapse‐free survival rate was 83.3%. The common Grade ≥3 treatment‐related adverse events were hematological toxicities (100.0%) and soft tissue infection (28.6%). No treatment‐related deaths occurred.
Conclusion:
Lipo‐MIT plus cytarabine showed a favorable PK profile and a manageable safety profile in newly diagnosed pediatric AML, with early evidence of clinical activity in this population.Clinical Trial Registration
: Chinese Clinical Trial Registry: ChiCTR2300067964 (
https://www.chictr.org.cn/showproj.html?proj=188738
).
2026-07-01·CELL TRANSPLANTATION
Efficacy and safety of mitoxantrone hydrochloride liposome/ thiotepa/ busulfan/fludarabine (MTBF) conditioning regimen for salvage allogeneic hematopoietic stem cell transplantation in patients with relapsed or refractory acute myeloid leukemia: A single - Arm prospective clinical trial
Article
作者: Zhang, Tongxin ; Ren, Juan ; Wang, Xiaoning ; Liu, Ruimin ; He, Pengcheng ; Zhu, Huachao ; Wang, Yuqi
To investigate the efficacy and safety of MTBF as conditioning regimen for salvage allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with relapsed or refractory acute myeloid leukemia (R/R AML). We conducted a single-arm prospective clinical trial (NCT06385808). The main outcome was cumulative incidence of relapse (CIR), and the secondary outcomes were progression-free survival (PFS), overall survival (OS), engraftment time, graft-versus-host disease (GVHD), and non-hematological adverse effects. Twenty-four R/R AML patients from the First Affiliated Hospital of Xi’an Jiaotong University were enrolled, and all achieved engraftment. Mucositis was the predominant toxicity and was managed appropriately. The two-year CIR was 10%. The two-year OS and PFS were 78.9 ± 11.1% and 51.2 ± 19.3%, respectively. Two patients experienced relapse, and three patients died of infection. Subgroup analyses demonstrated that maintenance treatment post-transplantation may improve OS. The MTBF regimen for salvage allo-HSCT in R/R AML exhibited notable anti-leukemia activity and tolerable toxicity. (NCT06385808, Efficacy and Safety of MTBF Conditioning Regimen for Salvageable Allo-HSCT in the Treatment of R/R AML).
2026-04-01·CANCER
Combination of mitoxantrone hydrochloride liposome with cyclophosphamide, vincristine, and prednisone for patients with treatment‐naive peripheral T‐cell lymphoma: A multicenter, open‐label, single‐arm, phase 1b trial
Article
作者: Zhou, Hui ; Zhang, Liling ; Gao, Yan ; Yan, Xiaojing ; Wang, Xin ; Jiang, Ming ; Liu, Lihong ; Li, Yufu ; Huang, Huiqiang ; Zhang, Xuanye
Abstract:
Background:
Peripheral T‐cell lymphoma (PTCL) is a heterogeneous group of lymphomas. Most subtypes are generally associated with a poor prognosis when treated with standard chemotherapy.
Methods:
This study enrolled patients with untreated PTCL who received mitoxantrone hydrochloride liposome (Lipo‐MIT) plus cyclophosphamide, vincristine, and prednisone (CMOP) every 4 weeks for six cycles. The study consisted of a 3 + 3 dose‐escalation phase (Lipo‐MIT at 12, 15, 18, and 21 mg/m
2
) and a specific dose‐expansion phase (Lipo‐MIT at the recommended phase 2 dose [RP2D]).
Results:
Between December 21, 2020, and November 17, 2022, 38 patients were enrolled. No dose‐limiting toxicities were reported, and the RP2D was established at 18 mg/m
2
. Grade ≥3 treatment‐related adverse events occurred in 33 (86.8%) patients, with the most common being neutrophil count decrease (76.3%) and white‐cell count decrease (73.7%). No treatment‐related deaths occurred. Among the 35 response‐evaluable patients, the independent review committee‐assessed complete response rate (CRR) was 54.3% (95% CI, 36.6%–71.2%), and the overall response rate (ORR) was 88.6% (95% CI, 73.3%–96.8%). For the 17 patients treated at RP2D, the CRR, ORR, median duration of CR, and median duration of response were 64.7% (95% CI, 38.3%–85.8%), 94.1% (95% CI, 71.3%–99.9%), 28.0 (95% CI, 9.8–46.3) months, and 28.0 (95% CI, 4.0–52.1) months, respectively. At a median follow‐up of 23.8 months, the median progression‐free survival was 20.8 (95% CI, 6.1–35.5) months, and the median overall survival was not reached. Lipo‐MIT exhibited a favorable pharmacokinetics (PK) profile.
Conclusion:
The CMOP regimen demonstrates a favorable PK profile, a manageable safety profile, and encouraging preliminary antitumor activity.
103
项与 盐酸米托蒽醌脂质体 相关的新闻（医药）2026-08-21
·证券之星
证券之星消息，近期石药集团（01093.HK）发布2026年中期财务报告，报告中的管理层讨论与分析如下：业务回顾：成药业务 2026年上半年,医药政策及行业形势变化主要包括以下几方面: –2026年3月,国家「十五五」规划首次将生物医药列为国家「新兴支柱产业」,并将生物制造列为未来产业,进一步强化了生物医药在国家产业体系中的战略定位。规划同时提出健全医疗、医保、医药协同发展和治理机制,推动「三医联动」从部门各自改革向系统协同治理升级。 –2026年2月至3月,第11批国采中选结果正式落地执行以及第1至8批国家药品集采统一接续采购周期正式执行,标志着集采规则持续调整完善,贯彻「稳临床、防内卷」的指导原则,并通过医疗机构按厂牌报量等机制,使集采竞争逐步从单纯的低价比拚转向以质量与品牌能力为核心的竞争,进而推动医药产业结构优化与行业集中度提升。 –2026年4月,国务院办公厅印发《关于健全药品价格形成机制的若干意见》,提出在全周期、全渠道、全领域健全价格形成机制,为药品价值实现与市场有序竞争提供制度支撑。 –2026年7月,国家卫健委发布2026版基药目录,该目录将对临床用药指南、处方集及医疗机构配备产生直接影响,并将于2026年9月1日起施行。届时,各医疗机构需要在规定时间内完成配备调整,未进入目录的品种可能面临临床使用场景收窄的压力。 积极应对市场挑战,推动多元化收入增长 面对上述政策变化,本集团一方面积极把握政策机遇及应对市场挑战,持续推进学术开拓、市场下沉及零售渠道拓展等多元化策略,以提升产品市场渗透率和品牌影响力。2026年上半年,本集团成药收入同比录得较大幅度增长。另一方面,本集团坚持「练内功」与「强研发」并重,持续加大研发投入,推动新产品加速上市。通过强化创新能力,开发具备独特市场优势的产品,提升整体产品线竞争力;同时积极推进国际化布局,依托对外授权与国际合作拓展海外市场。目前上述战略已取得显着成效,产品授权收入已成为集团第二增长曲线。2026年上半年,本集团授权费收入人民币58.95亿元,同比增长448.5%。 成药业务于2026年上半年录得收入人民币160.61亿元(包括授权费收入人民币58.95亿元),较去年同期增长56.7%,成药业务收入的分析如下: (人民币千元)(人民币千元) 按治疗领域 神经系统 主要产品包括:恩必普(丁苯酞软胶囊╱注射液)、明复乐(注射用重组人TNK组织型纤溶酶原激活剂)、舒安灵(己酮可可碱缓释片╱注射液)、恩理维(拉考沙胺注射液╱片)、恩悉(盐酸普拉克索片)、欧舒安(帕利哌酮缓释片)、欧悦欣(琥珀酸地文拉法辛)及欧来宁(奥拉西坦胶囊╱注射用奥拉西坦)等。 –恩必普 恩必普是中国脑血管病领域首个拥有自主知识产权的化学1类创新药,累计获得36项来自专业机构与临床指南的推荐,主要用于缺血性卒中及相关疾病的治疗,已成为该适应症临床诊疗中的核心用药之一。目前恩必普已开展4项「十四五」课题研究,其中2025年启动的轻型卒中BLESS研究与脑小血管病IMPACT研究,旨在为恩必普的序贯治疗方案及6个月至1年的长程用药策略积累高级别临床证据,进一步巩固其在卒中管理中的临床地位。2026年7月,恩必普胶囊和注射液双剂型均进入《国家基本药物目录(2026年版)》,将极大地有利于基层市场的开发与应用。 –明复乐 明复乐是公司自主研发的第三代特异性溶栓药,拥有完全自主知识产权,作为中国首个获批急性缺血性卒中(AIS)适应症的替奈普酶产品,已被列入多个临床治疗指南。2026年1月,美国心脏协会(AHA)与美国卒中学会(ASA)联合发布《2026年急性缺血性卒中早期管理指南》,正式将替奈普酶提升为与阿替普酶同等地位的一线静脉溶栓药物。作为中国原创替奈普酶的代表,明复乐获得国际权威指南的正式认可。2026年上半年,明复乐相关四项研究成果(TRACE-5、OPTION、INSTANT、TAPIS)相继刊发于全球四大顶级医学期刊,持续夯实产品高级别循证证据体系,为更广范围的临床规范应用筑牢基础。目前针对明复乐的临床管线前瞻布局持续推进,已启动用于发病4.5–24小时急性缺血性卒中溶栓治疗的注册临床研究,若该适应症获批,明复乐有望未来成为国内首个覆盖24小时溶栓时间窗的溶栓药物,将进一步拓宽适用人群,持续释放产品长期价值。 –舒安灵 舒安灵是一种非选择性磷酸二酯酶抑制剂,凭藉多重机制协同改善微循环障碍。 其临床适用范围持续向内分泌科、肾内科等领域拓展。随着医生对产品认知的加深及基层市场的持续开拓,市场空间有望进一步扩大。 2026年上半年,恩必普持续深耕基层与院外市场,销售收入同比实现较大幅度增长;随着循证医学证据的不断夯实以及临床对特异性溶栓药物认知的提升,明复乐销售收入同比实现显着增长;欧悦欣和舒安灵的销售收入同比实现较大幅度增长;恩悉和欧舒安的销售收入同比轻微下跌。 抗肿瘤 主要产品包括:多恩益(盐酸伊立替康脂质体注射液)、津优力(聚乙二醇化重组人粒细胞刺激因子注射液)、恩尼妥(安尼妥单抗注射液)、欣柏梓(注射用紫杉醇(白蛋白结合型)Ⅱ)、克艾力(注射用紫杉醇(白蛋白结合型))、多恩达(盐酸米托蒽醌脂质体注射液)、恩舒幸(恩朗苏拜单抗注射液)、戈瑞特(甲磺酸仑伐替尼胶囊)及津立泰(纳鲁索拜单抗注射液)等。 –多恩益 多恩益是中国首仿的盐酸伊立替康脂质体注射液,于2023年9月获批与5-氟尿嘧啶(5-FU)和亚叶酸(LV)联合,用于治疗接受吉西他滨治疗后进展的转移性胰腺癌患者。2025年12月多恩益获批新适应症,可与奥沙利铂、5-FU和LV联合用于转移性胰腺癌患者的一线治疗,成为国内首个获批用于胰腺癌一线治疗的伊立替康脂质体注射液。CSCO指南和CACA指南均将该联合方案列为转移性胰腺癌的一线和二线及以上治疗推荐方案。 –津优力 津优力是中国首个自主研发的长效升白药物,为治疗用生物制品1类新药。用于预防和治疗化疗患者因中性粒细胞减少而引起的感染和发热,该产品通过PEG修饰技术,显着提升了给药便利性与患者依从性,已获国内外权威指南一致推荐,并荣获多个国家级奖项。 –多恩达 多恩达是本集团自主研发的化学药品2类新药,2023年纳入国家医保目录,用于治疗复发╱难治性外周T细胞淋巴瘤,是全球首个上市的米托蒽醌纳米制剂,并已获得多项国家专利授权。目前,多恩达正持续推进外周T细胞淋巴瘤初治、弥漫大B细胞淋巴瘤、急性髓系白血病等多种血液肿瘤适应症的临床探索,并同步加快海外市场拓展,推动产品走向国际化应用。 –恩舒幸 恩舒幸是治疗用生物制品1类新药,本集团拥有发明专利及完全自主知识产权。该产品于2024年纳入国家医保目录。恩舒幸属重组抗PD-1全人源单克隆抗体,适用于既往接受至少一线含铂方案化疗失败的PD-L1表达阳性(CPS≥1)的复发或转移性宫颈癌的治疗。临床数据显示:恩舒幸在一线联合治疗复发转移宫颈癌患者的中位无进展生存期(mPFS)达到15.1个月,疗效显着优于同类产品;在二线及后线单药治疗复发转移宫颈癌患者的中位生存期(mOS)可达21.3个月。凭藉卓越的临床数据,该产品被纳入中华医学会、CSCO、CACA三大协会指南推荐。恩舒幸的市场推广主要集中在妇科肿瘤领域(包括宫颈癌和子宫内膜癌),同时也积极拓展其在食管癌、结直肠癌、非小细胞肺癌等实体瘤领域的临床研究。 –欣柏梓 欣柏梓于2026年6月获批上市,适应症为用于联合化疗失败的转移性乳腺癌或辅助化疗后6个月内复发的乳腺癌。III期临床研究验证了欣柏梓相较传统白紫在疗效方面实现显着提升—ORR提高10%(35.8%vs25.8%),mPFS延长1.5个月(8.31个月vs6.83个月),mOS未到达,死亡风险降低33%(HR=0.67),患者生存获益明确。 2026年上半年,本治疗领域销售收入同比小幅下跌4.3%,受医保价格下调的影响,多恩益的销售收入同比出现较大幅度下降;受益于产品循证优势的传递以及长效升白方案临床渗透率的提升,津优力的销售收入同比实现较大幅度增长;多恩达和恩舒幸的销售收入保持稳定增长。 抗感染 主要产品包括:安复利克(注射用两性霉素B胆固醇硫酸酯复合物)、安速利克(注射用两性霉素B脂质体)、维宏(阿奇霉素片╱胶囊╱肠溶片及注射用阿奇霉素)、舒罗克(注射用美罗培南)、诺莫灵(阿莫西林胶囊)、先曲(注射用头孢曲松钠)、先伍(注射用头孢唑林钠)以及欧健(头孢克肟胶囊)等。 –安复利克 安复利克于2021年3月经优先审评获批上市,并于同年进入国家医保目录,适用于深部真菌感染患者。本产品经过脂质结构修饰,极大降低了肾毒性和低钾血症的发生率,扩大了适用人群并有助于降低医疗成本,凭藉临床价值与社会需求,安复利克被国家工信部和卫健委联合推荐为「临床急需,市场短缺」的药品。 –安速利克 安速利克于2024年9月获批上市,属于多烯类抗生素,是作用最强、抗菌谱最广的侵袭性真菌病预防和治疗药物之一,其通过脂质体药物递送系统,将两性霉素B包裹在由氢化大豆磷脂酰胆碱、二硬脂酰磷脂酰甘油和胆固醇构成的小于100nm的小单室脂质体中。安速利克是国内首个通过一致性评价的两性霉素B脂质体,2025年通过医保谈判,全面取消医保支付范围限制,并于2026年1月落地执行,从而惠及更多抗真菌患者。并于2026年4月在欧盟获批上市,实现了中国脂质体制剂在欧洲市场的「零突破」。 2026年上半年,安速利克和维宏的销售收入同比实现大幅增长;安复利克、舒罗克及诺莫灵的销售收入保持稳定;受市场竞争和集采影响,欧健、先曲的销售收入同比有所下降。 心血管 主要产品包括:玄宁(马来酸左氨氯地平片╱分散片)、恩存(硫酸氢氯吡格雷片)、阿比康(阿司匹林肠溶片)、意舒宁(硝苯地平控释片)、明复乐(注射用重组人TNK组织型纤溶酶原激活剂,rhTNK-tPA)、达新宁(盐酸决奈达隆片)以及美洛林(替格瑞洛片)等。 –玄宁 玄宁主要用于治疗高血压与心绞痛(包括慢性稳定性心绞痛和血管痉挛性心绞痛),属于国家医保及基本药物品种。集团将持续采取全渠道推广策略,强化基层市场下沉与院内外患者流转,同时加大零售终端和线上平台的推广力度,充分发挥品牌优势,提升可及性与用药覆盖率。 –恩存 恩存是一种血小板聚集抑制剂,主要用于预防动脉粥样硬化引起的血栓形成事件,如心肌梗死和缺血性卒中。作为国内首个获得美国FDA认证的国产氯吡格雷,其采用与美国市场相同的工艺与生产线,实现中美同步上市,是国内外指南共识权威推荐的急性冠脉综合症(ACS)抗栓优选药物及卒中预防抗血小板的首选药物。 凭藉严格的质量管控和国际认证,恩存不仅在国内市场实现快速替代,销量仅次于原研并领先其他国产同类品牌,同时成功进入美国等海外市场,成为国产心血管药物走向国际化的典范。未来,公司将依托恩存的国际认证与市场优势,深化与海外药企的合作,持续巩固并扩大其在国内外市场的竞争优势。 –明复乐 明复乐是本集团基于中国人群基因序列自主研发的国产创新第三代特异性溶栓药,用于发病6小时内急性心肌梗死患者的溶栓治疗。凭藉卓越的疗效与良好的安全性,明复乐已被多部权威指南推荐为优选溶栓药物,包括《急性ST段抬高型心肌梗死溶栓治疗的合理用药指南(第2版)》、《ST段抬高型心肌梗死患者急诊PCI微循环保护策略中国专家共识》、《ST段抬高型急性心肌梗死院前溶栓治疗中国专家共识》及《急性ST段抬高型心肌梗死经皮冠状动脉介入治疗术中冠状动脉内溶栓专家共识(2025)》等。凭藉在心血管急救领域的临床优势,明复乐已成为该领域的重要治疗选择。 2026年上半年,玄宁、恩存、达新宁的销售收入同比保持稳定增长;受市场竞争和集采影响,美洛林和阿比康的销售收入同比出现一定回落。 呼吸系统 主要产品包括:伊络达(乙磺酸尼达尼布软胶囊)、恩益坦(注射用奥马珠单抗)、琦昕(磷酸奥司他韦胶囊)、诺一安(孟鲁司特钠片╱咀嚼片)、琦效(盐酸阿比多尔片)、中诺立克(盐酸氨溴索口服溶液)以及中诺平(盐酸氨溴索缓释片)等。 –伊络达 伊络达是中国首仿的尼达尼布制剂,适用于系统性硬化病相关间质性肺疾病(SSc-ILD)、具有进行性表型的慢性纤维化性间质性肺疾病(PF-ILD)以及特发性肺纤维化(IPF)的治疗。上述三项适应症均已纳入国家医保目录,为产品的稳健增长提供了有力支撑。 –恩益坦 恩益坦是中国首个按治疗用生物制品3.3类开发的茁乐生物类似药,适用于经过H1抗组胺药治疗后仍有症状的成人和青少年(12岁及以上)慢性自发性荨麻疹患者。2025年2月,恩益坦获批新增中至重度持续性过敏性哮喘适应症。《全球哮喘管理和预防策略》报告(GINA2024)指出,针对6岁以上的重症过敏性哮喘患者,强烈推荐采用IgE治疗(例如奥马珠单抗)。恩益坦通过严格的头对头临床研究验证了与原研药的临床等效性,并在上市后快速进入《中国过敏性哮喘诊疗指南(2025版)》与《慢性自发性荨麻疹诊疗指南》推荐路径,同时于2025年纳入国家医保目录。 2026年上半年,受集采和市场影响,伊络达和诺一安的销售收入同比有所下降;通过拓宽终端与双通道准入等策略,恩益坦的销售收入同比实现大幅增长。 消化代谢 主要产品包括:双乐欣(盐酸二甲双胍片╱缓释片)、欧倍妥(艾司奥美拉唑镁肠溶胶囊)、得必欣(奥美拉唑肠溶胶囊╱片╱注射剂)、艾普拉唑肠溶片、欣维平(阿卡波糖片)以及林美欣(格列美脲分散片)等。 –欧倍妥 欧倍妥是奥美拉唑S—异构体,作为质子泵抑制剂核心品种,具有更强的抑酸效果和更高的生物利用度,该产品被国内外权威指南一致推荐为治疗胃食管反流病与消化性溃疡的首选用药,并可与抗生素联合用于幽门螺杆菌(Hp)根除治疗。欧倍妥通过一致性评价和美国FDA认证,拥有原研级品质的同时极大的降低患者负担,是强效、起效快且适合初始及长期维持治疗的优选药物。 –得必欣 得必欣是一种经典的质子泵抑制剂,属于国家基本药物和医保甲类,受到国内外多项权威指南推荐,该产品适用于治疗由胃酸过多引起的多种胃部疾病。 2026年上半年,欣维平和得必欣的销售收入保持稳定增长;欧倍妥的销售收入同比有所下降。 其他治疗领域 主要产品包括:优得宁(塞来昔布胶囊)、奇迈特(盐酸曲马多片)、欧维(甲钴胺片)、氯化钠注射液、高顺松(阿西美辛缓释胶囊)、盐酸利多卡因注射液及固邦(阿仑膦酸钠片╱肠溶片)等。 原料产品业务 2026年上半年,原料产品业务录得销售收入人民币16.60亿元,较去年同期减少20.0%。 维生素C 2026年上半年,维生素C产品的销售收入为人民币10.10亿元,较去年同期减少15.5%。收入同比减少主要受产品售价下行影响;同时,行业产能释放带来供给增加、竞争加剧,致使市场整体价格走低。本集团将持续夯实产品质量、优化客户服务,并稳步拓展海外销售渠道,持续提升市场占有率。 抗生素 2026年上半年,抗生素产品的销售收入为人民币6.50亿元,较去年同期减少26.0%。主要是受市场竞争加剧以及下游产品第11批集采中选的影响。报告期内,青霉素类和7-ACA的销售量和价格均有所下滑;培南类产品销售量有一定程度的下降。 功能食品及其他业务 2026年上半年,功能食品及其他业务录得销售收入人民币8.73亿元,较去年同期减少8.2%,主要是由于期内咖啡因及无水葡萄糖的销售量和价格下降。 研发 本期的研发费用为人民币30.29亿元,较去年同期增加12.9%,约占成药业务收入29.8%(撇除授权费收入的影响)。目前有130余项产品在不同的临床研发阶段,其中针对16个适应症的上市申请已递交,近30个重点产品处于注册临床阶段。 注册审批进展 自2026年年初至今,本集团在中国的注册审批进展为:6款新产品获批上市;9款产品上市申请获得受理;获得3项突破性治疗认定;获得21项临床试验批件。此外,本集团在海外地区获得9项临床试验批件,在欧盟获得1项自主研发药物的上市批准。 中国 获批上市 上市申请获受理 2026年6月SYH9056片(缬沙坦马来酸单药治疗不能有效控制的原发性轻中度高 (KN026)╱注射用多西他赛乳腺癌 (白蛋白结合型)(HB1801) 获授予突破性治疗认定(BTD) (白蛋白结合型)(HB1801)╱受体2(HER2)阳性成人乳腺癌 安尼妥单抗注射液(KN026) 获得临床试验批件 首发适应症 新增适应症 海外 获美国FDA授予临床试验批件 获欧洲上市批准 获得注册批件 本集团自2026年初至今共获得5款仿制药品注册批件,分别为布地奈德肠溶胶囊、兰索拉唑肠溶胶囊、蔗糖铁注射液、布瑞哌唑片、恩格列净二甲双胍缓释片。 报告期内主要临床研究进展 关键临床启动 奥曲肽长效注射液 –2026年5月,在中国开展的奥曲肽长效注射液用于肢端肥大症治疗的Ⅲ期临床研究,实现首家中心启动。 CM326注射液 –2026年1月,在中国开展的CM326注射液治疗中重度哮喘III期临床研究,完成首家中心启动。 –2026年2月,在中国开展的CM326注射液治疗慢性鼻窦炎伴鼻息肉(CRSwNP)III期临床研究,实现首家中心启动。 普康安尼妥单抗(JSKN003) –2026年2月,在中国开展的普康安尼妥单抗治疗三线HER2阳性晚期结直肠癌III期临床研究,实现首家中心启动。 安尼妥单抗注射液(KN026) –2026年2月,在中国开展的安尼妥单抗注射液联合多西他赛白蛋白和化疗用于HER2阳性乳腺癌辅助治疗的III期临床研究,完成首家中心启动。 SYH2053注射液(PCSK9SiRNA) –2026年2月,在中国开展的SYH2053注射液联合他汀用于治疗原发性高胆固醇血症和混合型血脂异常的III期临床研究,实现首家中心启动。 –2026年2月,在中国开展的SYH2053注射液用于治疗原发性高胆固醇血症和混合型血脂异常的III期临床研究,实现首家中心启动。 –2026年3月,在中国开展的SYH2053注射液联合他汀治疗杂合子型家族性高胆固醇血症III期研究,实现首家中心启动。 注射用紫杉醇阳离子脂质体 –2026年3月,在中国开展的联合系统性治疗一线结直肠癌肝转移的Ib/III期临床研究,实现III期阶段,首家中心启动。 SYS6010(EGFRADC) –2026年3月,在中国开展的注射用SYS6010对照研究者选择化疗,用于治疗2L食管鳞癌的III期临床研究,实现首家中心启动。 –2026年3月,在中国开展的注射用SYS6010对照多西他赛治疗2L驱动基因阴性非鳞非小细胞肺癌(NSCLC)III期临床研究,实现首家中心启动。 –2026年3月,在中国开展的注射用SYS6010对照研究者选择的化疗治疗HER2阴性EGFR阳性乳腺癌III期临床研究,实现首家中心启动。 –2026年6月,在中国开展的注射用SYS6010联合恩朗苏拜单抗用于非小细胞肺癌辅助治疗III期临床研究,实现首家中心启动。 –2026年6月,在中国开展的注射用SYS6010联合恩朗苏拜单抗用于治疗一线驱动基因阴性PD-L1阳性非小细胞肺癌的III期临床研究,实现首家中心启动。 SYHA1813口服液 –2026年5月,在中国开展的SYHA1813口服液用于复发或进展高级别脑膜瘤治疗的III期临床研究,实现首家中心启动。 贝派度酸片 –2026年6月,在中国开展的贝派度酸片联合他汀用于高脂血症的III期临床研究,实现首家中心启动。 阿普昔腾坦片 –2026年6月,在中国开展的阿普昔腾坦片用于难治性高血压治疗的III期临床研究,实现首家中心启动。 注射用SYS6043 –2026年7月,在中国开展的注射用SYS6043对照研究者选择的化疗用于治疗铂耐药卵巢癌的III期临床研究,实现首家中心启动。 关键临床末例参与者入组 SYS6010(EGFRADC) –2026年2月,在中国开展的注射用SYS6010对照含铂化疗治疗二线EGFR突变的非小细胞肺癌III期临床研究,完成末例参与者入组。 普卢格列汀片(联合) –2026年3月,在中国开展的联合达格列净和二甲双胍治疗2型糖尿病的III期临床研究,完成末例参与者入组。 盐酸阿姆西汀肠溶片 –2026年4月,在中国开展的盐酸阿姆西汀肠溶片治疗抑郁症的III期临床研究,完成末例参与者入组。 SYH2053注射液(PCSK9SiRNA) –2026年4月,在中国开展的SYH2053注射液用于治疗原发性高胆固醇血症和混合型血脂异常的III期临床研究,完成末例参与者入组。 –2026年5月,在中国开展的SYH2053注射液联合他汀用于治疗原发性高胆固醇血症和混合型血脂异常的III期临床研究,完成末例参与者入组。 SYHX1901片 –2026年4月,在中国启动的SYHX1901片用于中重度斑块状银屑病治疗的III期研究,完成末例参与者入组。 JMT101注射液 –2026年5月,JMT101注射液联合奥希替尼用于一线EGFR经典突变的非小细胞肺癌的III期临床研究,完成末例参与者入组。 关键临床获得统计分析结果 安尼妥单抗注射液(KN026) –2026年4月,在中国开展的安尼妥单抗注射液联合多西他赛(白蛋白结合型)对比曲妥珠单抗和帕妥珠单抗联合多西他赛注射液治疗HER2阳性乳腺癌新辅助III期临床研究,完成TFL定稿,结果符合预期。 –2026年6月,在中国开展的安尼妥单抗注射液联合多西他赛(白蛋白结合型)对比曲妥珠单抗和帕妥珠单抗联合多西他赛注射液治疗一线HER2阳性晚期乳腺癌的III期临床研究在预设的期中分析达到主要终点。 司库奇尤单抗注射液 –2026年1月,在中国开展的司库奇尤单抗注射液治疗中重度斑块状银屑病III期临床研究,完成临床试验总结报告。 右美沙芬安非他酮缓释片 –2026年3月,在中国开展的右美沙芬安非他酮缓释片治疗成人抑郁症的III期临床试验,定稿临床试验总结报告。 TG103注射液(GLP-1受体激动剂) –2026年2月,在中国开展的TG103注射液治疗2型糖尿病的III期临床研究TFL定稿,结果符合预期。 –2026年2月,在中国开展的TG103注射液联合二甲双胍治疗2型糖尿病III期临床研究TFL定稿,结果符合预期。 缬沙坦马来酸左氨氯地平片 –2026年4月,在中国开展的治疗单药治疗不能有效控制的原发性轻、中度高血压的III期临床研究TFL定稿,结果符合预期。 盐酸阿姆西汀肠溶片 –2026年7月,在中国开展的盐酸阿姆西汀肠溶片治疗抑郁症的III期临床研究,达到主要研究终点。 注射用西罗莫司(白蛋白结合型) –2026年4月,在中国开展的注射用西罗莫司(白蛋白结合型)对照研究者选择方案治疗晚期恶性PEComa的Ib/III期临床研究达到主要终点。 重要数据发表 SYS6010治疗晚期实体瘤I期临床2026年美国癌症研究协会(AACR)年会—特邀口头报告试验—(鼻咽癌数据) SYS6010+SG001—晚期肺癌队列2026年世界肺癌大会(WCLC)—口头报告 —II期项目 SYS6010-001—晚期实体瘤—CancerCell(IF:56.1) I期(NSCLC数据) 专利数据 2026年1月至2026年7月,本集团共提交PCT国际专利申请54件,专利申请507件(国内170件和国外337件);此外,本集团获得专利授权44件(国内15件、国外29件)。 于2026年7月31日,本集团累计共提交PCT国际专利申请315件,专利申请3,063件(国内1,781件和国外1,282件);此外,本集团累计共获得专利授权1,098件(国内685件和国外413件)。 业务拓展 本集团持续强化内部创新能力,研发投入逐年增加,目前已形成丰富的研发管线,并积累了众多优质创新资产。近年来,我们通过对外授权创新产品以及与跨国制药企业达成战略合作,积极推动研发管线的国际化布局,加速创新成果的全球转化。 对外授权 缓释给药技术平台及多肽药物AI发现平台 2026年1月,本集团与阿斯利康签订了战略合作与授权协议,以利用本集团的缓释给药技术平台及多肽药物AI发现平台,开发创新长效多肽药物。阿斯利康获得本集团每月一次注射用体重管理产品组合的全球独家权利(不含中国内地、香港特别行政区、澳门特别行政区及台湾地区)。本集团将获得12亿美元的首付款,并有权获得最高35亿美元的潜在研发里程碑付款和最高138亿美元的潜在销售里程碑付款,以及最高达双位数比例的分层销售提成。 本集团于2026年5月29日收到协议项下12亿美元首付款,并在2026年7月10日收到2,500万美元研发里程碑款项,里程碑达成标志相关研发工作按计划稳步推进。 siRNA药物研发平台 2026年7月,本集团与阿斯利康订立合作、选择权及授权协议,依托本集团siRNA药物发现平台及肝外靶向递送平台,合作开发新型小核酸候选药物。双方针对两个靶点研发具有治疗肾脏疾病多种适应症潜力临床前候选药物;阿斯利康将有权选择获取在全球范围内或中国以外地区(视乎何者适用而定)开发、生产和商业化的权益。本集团将收取3,000万美元首付款,并有权收取最高5.4亿美元研发里程碑款项、最高12.0亿美元销售里程碑款项,以及个位数比例的销售提成。 本集团已于2026年8月12日收到协议项下3,000万美元首付款。该首付款之收取标志着双方合作之顺利推进,有利于本集团之整体战略布局,加速小核酸管线开发。 成立合资公司 2026年8月,本集团与阿斯利康就成立合资公司(‘该合资公司’)签署合资合同,在中国石家庄建设新一代生物制剂生产基地。该合资公司旨在结合本集团以人工智能驱动的良好生产规范(GMP)体系、药品生产建设及运营能力,以及阿斯利康在全球质量标准及供应链管理的专业优势,致力于向全球患者提供高质量药品。本集团与阿斯利康将分别按51%及49%股权比例出资,并依托各自的专业优势共同管理该合资公司的建设与日常营运。本次双方共同设立合资公司,有助于将本集团在高自动化、智能化、精益化生产基地建设及现行良好生产规范(cGMP)运营方面的优势,与阿斯利康的全球质量体系及供应管理经验相结合,从而打造符合国际市场需求的高质量生产能力。业务展望：面向未来,本集团将持续以技术创新驱动发展,以扎实的商业化能力落地成果,助力中国医药产业实现高质量发展,为更多患者带来福祉。以上内容为证券之星据公开信息整理，仅供参考不构成投资建议。相关 ETF
2026-07-23
BMC Medicine [Jour] AND 24[volume] AND 1[issue]（first half of the year）
生物医学中心 - 医学 24卷 1期（上半年）
https://link.springer.com/journal/12916/volumes-and-issues/24-1
369 articles in this issue
Impact of a real-time automatic quality control system for magnetically controlled capsule gastroscopy: a multicenter randomized controlled trial
磁控胶囊胃镜实时自动质量控制系统的效果：一项多中心随机对照试验
Xiaoya WangDawei ShenZhen Li
Research 02 May 2026
Article: 369
Lipid levels and risk-stratified management gaps of dyslipidemia in China
中国血脂水平及血脂异常风险分层管理差距
Long ZhangXu LiuJianping Li
Research 02 May 2026
Article: 368
Medicine price and affordability in China and selected ASEAN countries: a cross-country comparison with forward-looking implications for regional pooled procurement
中国与部分东盟国家的药品价格和可负担性：对区域集中采购前瞻性影响的跨国比较
Zhuangqi LiShuting ZhangBao Liu
Research 02 May 2026
Article: 367
Dementia risk by metabolic health and obesity in two prospective cohorts
两项前瞻性队列研究中代谢健康和肥胖对痴呆风险的影响
Martin NakashElsa Ojalehto LindforsIda K. Karlsson
Research 19 June 2026
Article: 366
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Maternal B-vitamin status modifies the risk of congenital heart disease in offspring associated with prenatal persistent organic pollutants exposure
母体B族维生素状况会改变胎儿在宫内持续暴露于有机污染物时先天性心脏病的患病风险
Sainan LiHai LinLinlin Wang
Research 04 May 2026
Article: 365
Obesity-derived metabolites modulate anti-tumor immunity in the tumor microenvironment: from mechanisms to clinical applications
肥胖衍生的代谢产物在肿瘤微环境中调节抗肿瘤免疫：从机制到临床应用
Yihang CaiJunyi JinXiaoying Li
Review 06 May 2026
Article: 364
Part of 1 collection:Tumor microenvironment in cancer therapy
所属专题合集：癌症治疗中的肿瘤微环境
Rational use of expensive medicines in the Netherlands: strategies to improve effectiveness and reduce burden on patients and society – a narrative review
荷兰高价药品的合理使用：提高疗效、减轻患者和社会负担的策略——一项叙述性综述
Bart M.F. PenninxSander W. TasCarla E.M. Hollak
Review 30 April 2026
Article: 363
NMR-based serum metabolite and lipoprotein profiling for endometriosis across clinically relevant and physiological comparator settings: assessment of diagnostic utility and exploratory biological signals
基于核磁共振（NMR）的血清代谢物和脂蛋白谱分析在子宫内膜异位症的临床相关和生理对照情况中的应用：诊断效用的评估和探索性生物信号的发现
Sisi DengAndré KochChristoph Trautwein
Research 17 June 2026
Article: 362
Changes in olfactory function in children and adolescents with obesity following an inpatient weight loss program: a longitudinal study
住院减肥计划后肥胖儿童和青少年嗅觉功能的变化：一项纵向研究
Bea KlosHelene SauerIsabelle Mack
Research 17 June 2026
Article: 361
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减肥干预及其对健康的影响
The neuroimmune axis in breast cancer: from mechanistic insights to clinical applications
乳腺癌中的神经免疫轴：从机制研究到临床应用
Yimao WuKaiyu ZhangMeng-Yao Li
Review 30 April 2026
Article: 360
A biologically informed framework for instrument selection in dietary Mendelian randomization using chemosensory genetics
基于化学感觉遗传学的饮食孟德尔随机化工具选择生物学框架
Liang-Dar HwangCailu LinPaule V. Joseph
Research 01 June 2026
Article: 359
Efficacy and safety of cyclosporine plus luspatercept versus cyclosporine in newly diagnosed non-transfusion-dependent non-severe aplastic anemia: A prospective randomized trial
环孢素联合卢帕塞普特与单用环孢素治疗新发非输血依赖型非重型再生障碍性贫血的疗效和安全性：一项前瞻性随机试验
Zhuxin ZhangQinglin HuBing Han
Research 29 April 2026
Article: 358
Dietary intake and epigenetic aging in an African population: food groups, dietary patterns, and plant-based diets in the RODAM study
非洲人群的膳食摄入与表观遗传衰老：RODAM研究中的食物组、膳食模式与植物性饮食
Naomi C.S. AuwerdaMuhau. M. MungambaFelix P. Chilunga
Research 28 April 2026
Article: 357
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用
Mitoxantrone hydrochloride liposome (Lipo-MIT) combined with capecitabine in HER2-negative advanced breast cancer: a dose-escalation, phase I study
米托蒽醌盐酸盐脂质体（Lipo-MIT）联合卡培他滨治疗HER2阴性晚期乳腺癌：一项剂量递增Ⅰ期研究
Jiaxuan LiuMingxia JiangQiao Li
Research 28 April 2026
Article: 356
Familial healthy aging and longevity: the role of spouses
家族健康衰老与长寿：配偶的作用
Søren NetraAngéline GalvinKaare Christensen
Research 28 April 2026
Article: 355
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用
Peripheral blood biomarkers RCAN1, Clusterin, RAGE, and malondialdehyde for early diagnosis and progression of Alzheimer’s disease
外周血生物标志物RCAN1、Clusterin、RAGE和丙二醛用于阿尔茨海默病的早期诊断与进展监测
Aurora Román-DomínguezCristina Mas-BarguesJosé Viña
Research 27 April 2026
Article: 354
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用
Palliative care for the people without medical insurance in Germany: an empirical ethical approach
德国无医疗保险人群的姑息治疗：一种实证伦理方法
Matthias ZimmerAntonia Sahm
Research 11 June 2026
Article: 353
Part of 1 collection:Palliative care and medicine
所属专题合集：姑息治疗与姑息医学
Maternal factors associate with microbiota-derived extracellular vesicle profiles in pregnancy: a clinical cohort study
妊娠期母体因素与微生物衍生的细胞外囊泡特征的相关性：一项临床队列研究
Jenni TurunenKaisu KyröTerhi Ruuska-Loewald
Research 28 May 2026
Article: 352
Prenatal computed tomography (CT) and risk of congenital heart disease and cerebral palsy: A nationwide mother–child paired cohort study
产前计算机断层扫描（CT）与先天性心脏病及脑瘫风险：一项全国性母子配对队列研究
Tae Wook KangJihye HeoDanbee Kang
Research 27 April 2026
Article: 351
Therapeutic TG2 inhibition reverses systemic multiomic dysregulation in celiac disease
治疗性TG2抑制可逆转乳糜泻的系统性多组学失调
Valeriia DotsenkoHana Hien Leon behalf of the CEC-3 Investigators
Research 24 April 2026
Article: 350
Adulthood stressful life events as predictors of incident cardiovascular disease: insights from two prospective cohorts
成年期应激性生活事件作为心血管疾病新发预测因子：来自两项前瞻性队列的见解
Shuang WuSiqi LyuGregory Y. H. Lip
Research 24 April 2026
Article: 349
Camrelizumab plus apatinib for immune checkpoint inhibitor-naive patients with metastatic clear cell renal cell carcinoma after first-line tyrosine kinase inhibitor treatment failure: a single-arm phase 2 trial
卡瑞利珠单抗联合阿帕替尼用于免疫检查点抑制剂初治转移性透明细胞肾细胞癌一线酪氨酸激酶抑制剂治疗失败后：一项单臂Ⅱ期试验
Xiuyu CaiXia ZhengPei Dong
Research 24 April 2026
Article: 348
Introducing the need for a consensus-based framework for protocol modifications to improve trial trustworthiness
提出建立基于共识的方案修改框架以提升临床试验可信度的必要性
Cora BurgwinkelManon GicquelClara Locher
Debate 24 April 2026
Article: 347
Modelling the epidemic dynamics of HPV among women in China and optimization of ongoing cervical cancer elimination strategies
中国女性人群HPV流行动力学建模及宫颈癌消除策略优化
Yuwei LiYi-Fan LinJianxin Zhen
Research 22 April 2026
Article: 346
Multiparameter concept-based interpretable model for early breast cancer diagnosis and structured reporting: a multi-center, multi-reader, radiologist-in-the-loop study
基于多参数概念的可解释模型用于早期乳腺癌诊断与结构化报告：一项多中心、多读者、放射科医师参与的研究
Jiao QuYang LiuSu Lui
Research 23 April 2026
Article: 345
Blood-based DNA methylation marker model for short-term and long-term lung cancer risk prediction
基于血液DNA甲基化标志物模型的肺癌短期与长期风险预测
Megha BhardwajYi-Qian SunHermann Brenner
Research 06 June 2026
Article: 344
Integrated serum proteomic and liver genomic analyses identify molecular signatures associated with metabolic dysfunction-associated steatotic liver disease: a multi-cohort study
整合血清蛋白质组学与肝脏基因组学分析鉴定与代谢功能障碍相关脂肪性肝病相关的分子特征：一项多队列研究
Jinjian XuWanglong GouYu-ming Chen
Research 17 April 2026
Article: 343
Predicting amyotrophic lateral sclerosis stage based on multi-parameter ultrasound: development and validation of an interpretable machine learning model
基于多参数超声预测肌萎缩侧索硬化症分期：可解释机器学习模型的构建与验证
Tianhua YangYing WangGaoyi Yang
Research 22 April 2026
Article: 342
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与更新
Duration of anti-seizure medicines started for acute symptomatic seizures due to acute meningitis: a systematic review and meta-analysis
急性脑膜炎所致急性症状性发作的抗癫痫药物起始疗程：一项系统综述与荟萃分析
Manya PrasadAmit KumarTarun Dua
Research 22 April 2026
Article: 341
Part of 1 collection:Acute meningitis: a collection of systematic reviews
所属专题合集：急性脑膜炎：系统综述集
Prenatal exposure to flood and risk of low birth weight: a multi-country study from 36 African countries
产前遭遇洪水与低出生体重风险：来自36个非洲国家的多国研究
Qian LiQian LiFengchao Liang
Research 21 April 2026
Article: 340
Part of 1 collection:Climate change and human health
所属专题合集：气候变化与人类健康
Sunshine duration and episodes of mental disorders and the inverse effect modification by ambient temperature
日照时长与精神障碍发作及环境温度的逆效应修饰
Lijun BaiJuan ChenShaowei Wu
Research 21 April 2026
Article: 339
The role of continuous glucose monitoring for diagnosis of gestational diabetes: exploring the potential
持续葡萄糖监测在妊娠糖尿病诊断中的作用：潜力探索
M. CrowleyC. NewmanF. P. Dunne
Review 21 April 2026
Article: 338
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题合集：妊娠糖尿病的诊断与治疗
Pre-diagnostic biomarkers and risk of stress-related disorders: a cohort study based on electronic health records
应激相关障碍诊断前生物标志物与风险：一项基于电子健康记录的队列
Anna A. PeltolaEsha KhanJake Lin
Research 01 June 2026
Article: 337
Epigenome-wide analysis of DNA-methylation signatures following climate-related disasters
气候相关灾害后DNA甲基化信号的全表观基因组分析
Wenzhong HuangRongbin XuYuming Guo
Research 20 April 2026
Article: 336
Part of 1 collection:Climate change and human health
所属专题合集：其后变化与人类健康
Redeemed prescription medicines to measure quality of life of patients with long-term conditions: a national cross-sectional study
通过已兑换的处方药衡量慢性病患者生活质量：一项全国性横断面研究
Henrik Hedegaard Pliess LarsenVolkert SiersmaAnne Holm
Research 20 April 2026
Article: 335
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
属于专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Viral shedding dynamics in coxsackievirus A6 hand, foot, and mouth disease: a prospective, individual-level analysis
柯萨奇病毒A6型手足口病的病毒排毒动态：一项前瞻性个体水平分析
Jiale MengYue ChengLu Long
Research 18 April 2026
Article: 334
Mental health and wellbeing interventions for uniformed service personnel: a mixed methods systematic review
军警人员心理健康与福祉干预措施：一项混合方法系统综述
Jessica EatonHolly EllardAlan Simpson
Research 17 April 2026
Article: 333
WISE-Therapy (What’s Important: Schedule and Engage) and bouldering psychotherapy for depression: A randomized clinical trial
WISE-Therapy（智慧疗法）（重要之事：安排与参与）与抱石心理治疗用于抑郁症：一项随机临床试验
Johannes KornhuberPiotr LewczukKatharina Luttenberger
Research 27 May 2026
Article: 332
Handgrip weakness is associated with motor cortex atrophy in rheumatoid arthritis: a cross-sectional study with a hand exercise intervention
握力减弱与类风湿关节炎患者运动皮层萎缩相关：一项包含手部运动干预的横断面研究
Amanda L GustafssonRolf A HeckemannCaroline Wasén
Research 26 May 2026
Article: 331
Interpretable multimodal PET/CT-EHR fusion via mixture-of-experts for prognostic stratification in mantle cell lymphoma: a multicenter study
基于专家混合模型的可解释性多模态PET/CT-HER（电子健康记录）融合在套细胞淋巴瘤预后分层中的应用：一项多中心研究
Chong JiangZitong ZhangRong Tian
Research 16 April 2026
Article: 330
Non-invasive diagnosis strategy integrating PSMA PET/CT and mpMRI for patients with suspected prostate cancer: a multi-center study
整合PSMA PET/CT与多参数MRI的无创诊断策略用于疑似前列腺癌患者：一项多中心研究
Yuhang WangYongxiang TangYi Cai
Research 16 April 2026
Article: 329
Clinical benefit of tenecteplase despite failed recanalization in late-window ischemic stroke: a post hoc analysis of the TRACE-3 trial
晚期窗口缺血性卒中中即使再通失败，替奈普酶仍具临床获益：TRACE-3试验的事后分析
Zhengzhao LuZiran WangYongjun Wang
Research 16 April 2026
Article: 328
Infant subcortical brain volumes associated with maternal obesity and diabetes: a large multicohort human study
婴儿皮层下脑容量与母亲肥胖及糖尿病相关：一项大型多队列人类研究
Ann M. AlexJerod M. RasmussenENIGMA-ORIGINs working group
Research 16 April 2026
Article: 327
Cost-effectiveness of prehabilitation for elderly (pre-)frail patients prior to elective surgery compared to standard care - an economic evaluation from a societal perspective
择期手术前老年（衰弱前期/）衰弱患者预康复与标准护理的成本效益比较——一项基于社会视角的经济学评估
Tanja RombeyHelene EckhardtLukas Schöner
Research 21 May 2026
Article: 326
Frozen melanoma tissues yield extracellular vesicles with preserved diagnostic and immunogenic properties
冷冻黑色素瘤组织可获得具有保存完好的诊断和免疫特性的细胞外囊泡
Daniele D´ArrigoKyong-Su ParkRossella Crescitelli
Research 21 May 2026
Article: 325
Mechanisms underlying immunodynamics of layered defenses elicited by mRNA vaccination in children
儿童mRNA疫苗接种所引发的分层防御免疫动力学的潜在机制
Yiyu LiaoHoong Kai ChuaKeisuke Ejima
Research 15 April 2026
Article: 324
Epigenetic aging markers in the association between frailty and mortality among U.S. adults
美国成年人虚弱与死亡率相关性中的表观遗传衰老标志物
May A. BeydounNicole Noren HootenAlan B. Zonderman
Research 15 April 2026
Article: 323
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Evolution with age of the relationship between sex and post-COVID symptoms: a population-based cohort study
性别与新冠后遗症症状关系随年龄的演变：一项基于人群的队列研究
Anne PastorelloCécile Vuillermozfor the EpiCov study group
Research 14 April 2026
Article: 322
Bowel cancer care in individuals with an intellectual disability: a population-based cohort study of symptoms, diagnostic pathways, treatment and survival
智力障碍个体的肠癌护理：症状、诊断路径、治疗及生存的基于人群的队列研究
Oliver John KennedyUmesh ChauhanDarren Mark Ashcroft
Research 20 May 2026
Article: 321
Association of antiviral use for influenza among non-severe cases with subsequent hospitalization and mortality
非重症流感病例使用抗病毒药物与后续住院及死亡的关系
Taito KitanoShinya TsuzukiSayaka Yoshida
Research 06 April 2026
Article: 320
Social and digital engagement associated with reduced depressive symptoms in adults aged 50 and older: a multi-country cohort study
社交及数字互动与50岁及以上成年人抑郁症状减少的关系：一项多国队列研究
Yaping WangLiyuan TaoJue Liu
Research 07 April 2026
Article: 319
Fat-soluble vitamin deficiency in children with neurodevelopmental disorders: a cross-sectional study
神经发育障碍儿童脂溶性维生素缺乏：一项横断面研究
Jingjing RaoXiaomei WangChangzhen Li
Research 08 April 2026
Article: 318
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Skeletal and cardiac muscle longitudinal associations in the Baltimore Longitudinal Study of Aging (BLSA)
巴尔的摩老龄化纵向研究（BLSA）中骨骼肌与心肌的纵向关联
Jie Jun WongFei GaoAngela S. Koh
Research 06 April 2026
Article: 317
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用
Early repetitive transcranial magnetic stimulation for preventing chronic postoperative pain in older adults: a randomized clinical sub-study
早期重复经颅磁刺激预防老年患者慢性术后疼痛：一项随机临床子研究
Wei-Wei ZhouZhi YangChao-Chao Zhong
Research 06 April 2026
Article: 316
Part of 1 collection:Neuromodulation in brain functional disorders
所属专题合集：脑功能障碍中的神经调控
Clinical epidemiology and risk prediction of unsuccessful treatment outcomes in pulmonary tuberculosis with diabetes mellitus
合并糖尿病的肺结核治疗失败结局的临床流行病学与风险预测
Ping LiFeilong LuJunjun Jiang
Research 25 March 2026
Article: 315
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与感染性疾病
Spatiotemporal patterns of climate-sensitive vector-borne diseases in Bangladesh: leveraging machine learning and spatial regression for intervention strategies
孟加拉国气候敏感型虫媒传染病的时空格局：利用机器学习与空间回归制定干预策略
Md. Siddikur RahmanMd. Abu Bokkor ShiddikArman Hossain Chowdhury
Research 13 April 2026
Article: 314
Part of 1 collection:Climate change and human health
所属专题合集：气候变化与人类健康
The association of pregnancy complications/risk factors with the development of cancer in women: an umbrella review
妊娠并发症/危险因素与女性癌症发生的关系：一项伞状综述
Jemma HealeyMegha SinghMairead Black
Research 13 April 2026
Article: 313
Synergistic effects of obesity and type 2 diabetes on adiposity-related cancer risk across age strata
肥胖与2型糖尿病对不同年龄层肥胖相关癌症风险的协同效应
Alex E. HenneyMegan HeagueDaniel J. Cuthbertson
Research 13 April 2026
Article: 312
Acute COVID-19 severity and impaired cognitive function up to 32months after diagnosis: an observational study
急性新冠严重程度与确诊后长达32个月的认知功能损害：一项观察性研究
Ingibjörg MagnúsdóttirAnders B. NygaardUnnur Anna Valdimarsdóttir
Research 11 April 2026
Article: 311
Maternal macronutrient intake and gestational diabetes: systematic review of prospective observational studies and dose-response meta-analyses
孕产妇宏量营养素摄入与妊娠期糖尿病：前瞻性观察研究的系统综述及剂量反应荟萃分析
Cameron D. YoungMichael G. GarrattAndrew N. Reynolds
Research 11 April 2026
Article: 310
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题合集：妊娠期糖尿病的诊断与管理
Global, regional, and national burden of colorectal cancer attributable to central obesity: a population attributable fraction analysis
中心性肥胖所致结直肠癌的全球、区域及国家负担：人群归因分数分析
Daniele PiovaniGisella FiglioliStefanos Bonovas
Research 10 April 2026
Article: 309
Evaluating DNA methylation markers and extended HPV genotyping in first-void urine for detecting high-grade cervical lesions in HPV-positive women: a cross-sectional study
评估首段尿液中DNA甲基化标志物及扩展型HPV基因分型在HPV阳性女性中检测高级别宫颈病变的价值：一项横断面研究
Mette TranbergSeverien Van KeerRenske Steenbergen
Research 10 April 2026
Article: 308
Targeted long-read genomic and epigenomic profiling enhances timely comprehensive variant discovery in hypotonia and muscle weakness
靶向长读长基因组与表观基因组测序提升低张力与肌无力的全面变异及时发现
Eman AbuijlanShruti SinhaAhmad Abou Tayoun
Research 08 April 2026
Article: 307
Targeting immunosenescence in lung diseases: mechanistic insights and clinical interventions
靶向肺疾病中的免疫衰老：机制洞察与临床干预
Yin ZhangXianzhe YuFengming Luo
Review 08 April 2026
Article: 306
Apolipoprotein C3 drives adverse cardiac remodeling in ischemic heart failure
载脂蛋白C3促进缺血性心力衰竭中的不良心脏重塑
Yufei HanYixue ZhaoXunde Xian
Research 09 April 2026
Article: 305
Part of 1 collection:Cardiac immunity and inflammation
所属专题合集：心脏免疫与炎症
Causal modeling of school aversion in psychiatrically referred adolescents: a DoWhy-based analysis
转诊精神病科的青少年厌学情绪的因果模型：基于DoWhy的分析
Mengmeng ZhangXin MaMeijuan Wang
Research 09 April 2026
Article: 304
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Aperiodic and periodic neural activity during sleep in autism spectrum disorders
自闭症谱系障碍睡眠中的非周期性和周期性神经活动
Noemi MazzoniEva-Maria KurzAndrea Caria
Research 18 March 2026
Article: 303
Part of 1 collection:Sleep and mental health
所属专题合集：睡眠与心理健康
Association and mediating pathways between intergenerational educational mobility and depressive symptoms: findings from high- and middle-income countries
代际教育流动性与抑郁症状之间的关联及中介路径：来自高收入和中等收入国家的发现
Yingchao ZengSimu HuangChihua Li
Research 02 April 2026
Article: 302
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Scoping review on the prioritisation of high-consequence infectious pathogens for research preparedness and response to health emergencies
关于优先研究高后果性感染病原体以应对突发卫生事件的研究准备与响应的范围综述
Nicolas PulikHolly SadlerAlice Norton
Research 01 April 2026
Article: 301
Serum uric acid levels among children and adolescents in China: percentile reference values and national prevalence estimates of hyperuricemia
中国儿童和青少年血清尿酸水平：高尿酸血症的百分位参考值和全国患病率估计
Qianrang ZhuXin’nan ZongMin Zhao
Research 31 March 2026
Article: 300
Waist circumference and grip strength and their joint relations to type 2 diabetes incidence in UK Biobank
腰围和握力及其与英国生物银行中2型糖尿病发病风险的联合关系
Johanna WirlerMichael J. SteinMichael F. Leitzmann
Research 07 May 2026
Article: 299
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Targeting cardiomyocyte-derived extracellular vesicle miR-574-5p protects against cognitive impairment induced by ischemia–reperfusion
靶向心肌细胞衍生的外泌体miR-574-5p可预防缺血再灌注引起的认知障碍
Erya ChenXiaoyu ZhuChan Chen
Research 19 March 2026
Article: 298
Motor-related reorganization in left inferior frontal gyrus after subcortical stroke: neurochemical basis and response to targeted neuromodulation
皮层下卒中后左侧额下回的运动相关重组：神经化学基础及靶向神经调控的反应
Wenjun HongYaxi WangZhiyong Zhao
Research 27 March 2026
Article: 297
Part of 1 collection:Neuromodulation in brain functional disorders
所属专题合集：脑功能疾病中的神经调控
Association between ambient temperature and childhood vaccination coverage in low- and middle-income countries
中低收入国家环境温度与儿童疫苗接种覆盖率之间的关联
Hongqiu ZhengYixiang ZhuZhiyuan Hou
Research 11 March 2026
Article: 296
Part of 1 collection:Climate change and human health
所属专题合集：气候变化与人类健康
White matter changes in reward circuits of amyotrophic lateral sclerosis: a fixel-based study of appetite loss
肌萎缩侧索硬化症奖赏回路白质改变：基于纤维束的食欲减退研究
Jeryn ChangHarry LipscombeThomas B. Shaw
Research 27 March 2026
Article: 295
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
The adverse effects associated with tirzepatide use in patients at increased risk of cardiovascular events: a systematic review with meta-analysis and Trial Sequential Analysis
替西帕肽在心血管事件风险增加患者中的不良反应：一项系统综述与荟萃分析及试验序贯分析
Christina Dam Bjerregaard SillassenPascal FaltermeierJanus Christian Jakobsen
Research 27 March 2026
Article: 294
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减肥干预措施及其健康影响
Age-related genomic characterization and therapeutic targets in Chinese breast cancer: insights from prospective targeted sequencing and clinical data analysis
中国乳腺癌年龄相关基因组特征及治疗靶点：前瞻性靶向测序与临床数据分析的见解
Xin-Yi SuiXiao-Qing SongLei Fan
Research 27 March 2026
Article: 293
Impact of the family cohesion-centered frailty intervention on older gastric cancer patients: a non-randomized controlled trial
以家庭凝聚力为中心的衰弱干预对老年胃癌患者的影响：一项非随机对照试验
Yinning GuoYimeng ChenQin Xu
Research 27 March 2026
Article: 292
Part of 1 collection:Clinical trials for gastrointestinal cancer
所属专题合集：胃肠道癌症临床试验
Perceptions of HPV vaccination: a qualitative study with adolescents, parents, school staff, and pharmacists
对HPV疫苗接种的看法：一项针对青少年、家长、学校工作人员和药剂师的定性研究
Laurène HoutinLucia RomoClémence Brun
Research 26 March 2026
Article: 291
Risk classification of internet gaming disorder based on neurobiological subtyping from impulsivity-linked resting-state functional connectivity: a longitudinal design study
基于冲动性相关静息态功能连接神经生物学亚型的网络游戏障碍风险分类：一项纵向设计研究
Xinwen WenJiahao ZhaoKai Yuan
Research 26 March 2026
Article: 290
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Trainee-delivered school-based intervention with guided narrative writing for adolescent anxiety and depression: a cluster randomized controlled trial
由受训者实施的、基于学校的、以引导性叙事写作为干预手段的青少年焦虑和抑郁干预：一项整群随机对照试验
Yixuan WangMuyang LiYinyin Zang
Research 26 March 2026
Article: 289
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Nourishing future generations: the critical role of healthy school lunches and strategic food procurement
滋养未来一代：健康学校午餐和战略性食品采购的关键作用
Aurora Perez-CornagoCarmen Piernas
Comment 05 May 2026
Article: 288
Multi-omics analysis reveals sex-specific etiology of human muscle weakness following musculoskeletal injury
多组学分析揭示人类骨骼肌损伤后肌无力的性别特异性病因
Alexander R. KeebleAllison M. OwenChristopher S. Fry
Research 26 March 2026
Article: 287
Public health impact of catch-up vaccination or additional booster doses with pre-erythrocytic malaria vaccine R21/Matrix-M: a modelling study
使用红细胞前期疟疾疫苗R21/Matrix-M进行追赶接种或额外加强接种的公共卫生影响：一项建模研究
Kelly McCainHillary M. TopazianAzra C. Ghani
Research 25 March 2026
Article: 286
A digital-health multidomain lifestyle management framework and its associations with cardiometabolic health: a real-world observational study
数字健康多领域生活方式管理框架及其与心脏代谢健康的关联：一项现实观察性研究
Han XiaoKexin DingDafang Chen
Research 25 March 2026
Article: 285
Bilateral sequential accelerated theta-burst stimulation for treatment-resistant depression: an open-label randomized controlled trial
双侧序贯加速θ波爆发刺激治疗难治性抑郁症：一项开放标签随机对照试验
Xingxing LiEnze TangDongsheng Zhou
Research 25 March 2026
Article: 284
Part of 1 collection:Neuromodulation in brain functional disorders
所属专题合集：脑功能疾病中的神经调控
Digenic inheritance of mutations in SPG7 and AFG3L2 causes motor neuron and cerebellar disorders
SPG7和AFG3L2基因突变双基因遗传导致运动神经元和小脑疾病
Mehrdad A. EstiarEric YuZiv Gan-Or
Research 24 March 2026
Article: 283
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新颖动态
Social isolation and 59 common health conditions: insights from observational and genetics analyses
社交孤立与59种常见健康状况：观察性研究与遗传学分析的见解
Sizhi AiQiqi WuYannis Yan Liang
Research 23 March 2026
Article: 282
Clustering depression subgroups based on dorsolateral prefrontal-subgenual anterior cingulate cortex peak functional connectivity reveals different symptom profiles and TMS treatment outcomes
基于背外侧前额叶-膝下前扣带回皮层峰值功能连接性的抑郁亚组聚类分析揭示了不同的症状特征和经颅磁刺激（TMS）治疗结果
Gai KongSirui WangYingying Tang
Research 23 March 2026
Article: 281
Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behaviours
人类遗传学有力证据支持成纤维细胞生长因子21（FGF21）对减少饮酒行为的因果效应
Héléne T. CronjéSile HuDipender Gill
Research 23 March 2026
Article: 280
Artificial intelligence-based prediction of fetal hypoxia: a multicenter model development and nationwide AI-human comparison
基于人工智能的胎儿缺氧预测：多中心模型开发及全国范围的人工智能与人类对比
Suiwen LinXiaodan DiBin Liu
Research 21 March 2026
Article: 279
Efficacy and long-term engagement of a WeChat-integrated modality versus a traditional quitline on smoking cessation in China: a randomised controlled trial
微信整合模式与传统戒烟热线在中国戒烟中的疗效及长期参与度：一项随机对照试验
Shuilian ChuDi ZhangLirong Liang
Research 21 March 2026
Article: 278
A culturally-safe primary care intervention for migrant/refugee women suffering domestic violence and abuse: HARMONY—a pragmatic cluster randomised controlled trial
针对遭受家庭暴力和虐待的移民/难民妇女的文化安全初级护理干预措施：HARMONY——一项实用性整群随机对照试验
Angela J. TaftFelicity YoungGene Feder
Research 21 March 2026
Article: 277
Development, integration, retention, and career progression of physician associates/assistants in UK NHS hospitals and clinical teams: a multiple-case qualitative study
英国国家医疗服务体系（NHS）医院及临床团队中医师助理/协理医师的发展、整合、留任及职业晋升：一项多案例定性研究
Yingxi ZhaoRhys SwainstonThe ROADMAP-PA collaborator group
Research 20 April 2026
Article: 276
Compound climate extreme events and associated health impacts: a scoping review
复合气候极端事件及其相关健康影响：一项范围性综述
Shifali MathewsCaitlin WalkerJaime Madrigano
Research 20 March 2026
Article: 275
Part of 1 collection:Climate change and human health
所属专题合集：气候变化与人类健康
Smoking history, eligibility for lung cancer screening and risk of death by lung cancer or other causes -- a longitudinal, time-variable analysis of the EPIC-Heidelberg cohort
吸烟史、肺癌筛查资格以及死于肺癌或其他原因的风险——对EPIC-海德堡队列的纵向、时变分析
Yue ChenSrimanti DuttaRudolf Kaaks
Research 28 April 2026
Article: 274
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Cortical functional hierarchy disruption following subcortical stroke
皮质功能层级在皮层下卒中后的破坏
Ke WuGang LiuGaolang Gong
Research 19 March 2026
Article: 273
Characterizing the effects of genetic liability to autoimmune conditions on pregnancy outcomes using Mendelian randomization
利用孟德尔随机化方法表征遗传易感性对自身免疫性疾病患者妊娠结局的影响
Elisabeth AitonNancy S. McBrideMaria Carolina Borges
Research 19 March 2026
Article: 272
Dystrophin-gene mutation location influences severity of electroretinogram defects in mouse models of Duchenne muscular dystrophy
杜氏肌营养不良症小鼠模型中，肌营养不良蛋白基因突变位置对视网膜电图缺陷严重程度的影响
André Maurício Passos LiberMirella BarboniCyrille Vaillend
Research 25 April 2026
Article: 271
Personalizing the treatment of head and neck cancer in vitro: The 3D-OTC model
体外个性化治疗头颈部肿瘤：三维器官芯片（3D-OTC）模型
Fabian StögbauerTobias WeiserBarbara Wollenberg
Research 25 April 2026
Article: 270
Part of 1 collection:Organoids: connecting molecular insights and clinical practice
所属专题合集：类器官：连接分子见解与临床实践
Risk factor profiles for infections in individuals with type 2 diabetes: a prospective cohort study
2型糖尿病患者感染的风险因素特征：一项前瞻性队列研究
Han-Cheng YuJi-Juan ZhangYun-Fei Liao
Research 18 March 2026
Article: 269
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与感染性疾病
Cause-specific years of life lost attributable to non-optimal body mass index by county, sex, race, and ethnicity in the USA, 2000–2019: a systematic analysis of health disparities
2000-2019年美国按县、性别、种族和民族划分的非最佳体重指数导致的特定原因寿命损失年数：一项关于健康差异的系统分析
GBD US Health Disparities CollaboratorsFarah MouhannaLaura Dwyer-Lindgren
Research 18 March 2026
Article: 268
Global and regional prevalence, burden, and risk factors for MASLD in children and adolescents aged 5 to 24years: a systematic review, meta-analysis, and modeling study
全球和区域5至24岁儿童和青少年代谢相关脂肪性肝病（MASLD）的患病率、负担及风险因素：一项系统综述、荟萃分析和建模研究
Yunfei LiuShan CaiSusan M. Sawyer
Research 18 March 2026
Article: 267
Relative leukocyte telomere length and the risk of lung cancer progression in individuals with pulmonary nodules
相对白细胞端粒长度与肺结节患者肺癌进展风险的关系
Yuanyuan WuDong SunFeifei Cheng
Research 18 March 2026
Article: 266
Effects of Tai Chi combined with transcranial direct current stimulation on pain in knee osteoarthritis: a randomized controlled neuroimaging trial
太极拳结合经颅直流电刺激对膝骨关节炎疼痛的影响：一项随机对照神经影像学试验
Xuefeng LiuTong TangJing Tao
Research 17 March 2026
Article: 265
DNA hypermethylation of choline kinases drives blockage of choline-phosphatidylcholine biosynthesis: lipidomic biomarkers and epigenetic insights of hepatic steatosis induced by arsenic
胆碱激酶DNA高甲基化驱动胆碱-磷脂酰胆碱生物合成受阻：砷诱导的肝脂肪变性的脂质组学生物标志物及表观遗传学见解
Qiwen FuQi WangLu Ma
Research 17 March 2026
Article: 264
Dynamics of Mpox epidemics by the interplay of COVID-19 pandemic in Africa
非洲猴痘（Mpox）流行与新冠肺炎（COVID-19）大流行相互作用下的猴痘流行病学动态
Oyewole K. OyedeleNifarta P. AndrewAlash’le Abimiku
Research 17 March 2026
Article: 263
Part of 1 collection:Mpox: Epidemiology, prevention, and treatment
所属专题合集：猴痘：流行病学、预防和治疗
SPP1high fibrogenic macrophages mediate protective fibrotic remodeling and promote vascular stability in hypertension-associated aortic dissection
SPP1高表达成纤维性巨噬细胞介导保护性纤维化重塑并促进高血压相关主动脉夹层的血管稳定性
Shuai ZhaoXiumeng HuaJiangping Song
Research 16 March 2026
Article: 262
Longitudinal associations between body fat mass and cardiovascular outcomes among Chinese children: mediation by cardiometabolic risk factors
中国儿童身体脂肪量与心血管结局之间的纵向关联：通过心脏代谢风险因素的中介作用
Hui YangQin LiuBo Xi
Research 16 March 2026
Article: 261
The timing of the commencement of pulmonary rehabilitation in hospitalized patients with acute exacerbation of COPD: a systematic review and network meta-analysis
住院慢性阻塞性肺疾病急性加重患者开始肺康复治疗的时机：一项系统综述和网络荟萃分析
Peilin JiaHailong ZhangLongyu Wang
Research 16 March 2026
Article: 260
Correction: Vegetable intake and the risk of bladder cancer in the BLadder Cancer Epidemiology and Nutritional Determinants (BLEND) international study
更正：膀胱癌流行病学和营养决定因素（BLEND）国际研究中蔬菜摄入量与膀胱癌风险的关系
Evan Yi-Wen YuAnke WesseliusMaurice P. Zeegers
Correction 22 April 2026
Article: 259
Comparative efficacy of neoadjuvant short-course versus long-course radiotherapy-based regimens with or without immunotherapy for locally advanced pMMR rectal cancer: a systematic review and network meta-analysis
基于放疗的新辅助短疗程与长疗程治疗方案（联合或不联合免疫治疗）对局部晚期错配修复功能正常（pMMR）型直肠癌的疗效比较：一项系统综述与网状荟萃分析
Liqing LiXiaoyao MengTingshi Su
Research 14 March 2026
Article: 258
Association between bariatric surgery and long-term ability to perform household tasks in the Swedish Obese Subjects study: a controlled prospective cohort study
瑞典肥胖受试者研究：减肥手术与长期从事家务能力之间的关联——一项对照前瞻性队列研究
Petra BrembeckJohanna C. Andersson-AssarssonPer-Arne Svensson
Research 18 April 2026
Article: 257
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减重干预措施及其健康影响
The role of male foetal sex on maternal and neonatal outcomes in pregnancies complicated by gestational diabetes—secondary analysis of a randomised placebo controlled clinical trial of metformin in gestational diabetes (EMERGE)
男性胎儿性别对妊娠期糖尿病合并妊娠的母婴预后的影响——妊娠期糖尿病二甲双胍随机对照安慰剂临床试验（EMERGE）的二次分析
Christine NewmanAlberto Alvarez-IglesiasFidelma Dunne
Research 12 March 2026
Article: 256
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题合集：妊娠期糖尿病的诊断与管理
Downregulated lysyl oxidase in plasma extracellular vesicles: a biomarker linked to brain metastasis risk in lung adenocarcinoma
血浆细胞外囊泡中赖氨酰氧化酶表达下调：与肺腺癌脑转移风险相关的生物标志物
Jing LiYu PeiYi Liu
Research 12 March 2026
Article: 255
The influence of age-dependent susceptibility on RSV transmission dynamics and immunisation population-level impact
年龄依赖性易感性对呼吸道合胞病毒（RSV）传播动力学及免疫接种人群层面影响的研究
Chenkai ZhaoYuhe ZhangHarish Nair
Research 11 March 2026
Article: 254
A human-derived Bacteroides strain attenuates depressive-like behavior in a rat model of social defeat-induced stress
一株人源拟杆菌属菌株可减轻社会挫败诱导应激大鼠模型的抑郁样行为
Marisol I. DothardMariaelena CaboniPhilip Strandwitz
Research 10 March 2026
Article: 253
Adverse events in both childhood and adulthood are associated with molecular, clinical and functional markers of ageing
童年和成年期的不良事件均与衰老的分子、临床和功能标志物相关
Monica AasThole H HoppenJulian Mutz
Research 28 April 2026
Article: 252
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Genetic predisposition to high BMI, ultra-processed food consumptions in childhood, and adiposity in young adulthood: a 17-year prospective cohort study of 3061 individuals
高BMI遗传易感性、儿童期超加工食品摄入与成年早期肥胖：一项对3061例个体进行的为期17年的前瞻性队列研究
Ziyi ZhouQiaosen ChenFrederick K. Ho
Research 16 April 2026
Article: 251
Enhanced predictive performance of artificial intelligence in individualized ovarian stimulation of in vitro fertilization: a retrospective cohort study
人工智能在体外受精个体化卵巢刺激中的预测性能提升：一项回顾性队列研究
Guiquan WangMinyue TangYimin Zhu
Research 10 March 2026
Article: 250
PCDSOS: a novel clinical predictive tool for screening primary ciliary dyskinesia in adult bronchiectasis patients—a multicenter derivation and external validation study
PCDSOS：一种用于筛查成人支气管扩张症患者原发性纤毛运动障碍的新型临床预测工具——一项多中心推导及外部验证研究
Wangji ZhouLin WangXinlun Tian
Research 10 March 2026
Article: 249
Detection rate and mutational landscape in extracranial arteriovenous malformations: a cohort study
颅外动静脉畸形的检出率及突变谱：一项队列研究
Vanessa F. SchmidtDenny Schanzefor the APOLLON Investigators
Research 16 April 2026
Article: 248
Kinetics of antibodies and risk of respiratory syncytial virus infection: a longitudinal cohort in Taizhou City, eastern China
抗体动力学与呼吸道合胞病毒感染风险：中国东部台州市的一项纵向队列研究
Qiang WangDavid HodgsonWeibing Wang
Research 09 March 2026
Article: 247
Cell therapy strategies for organ regeneration
器官再生的细胞治疗策略
L. PapamichailL. J. W. van der LaanM. J. Hoogduijn
Review 25 February 2026
Article: 246
Transcutaneous spinal cord stimulation combined with robot-assisted gait training to improve mobility and balance in spinal cord injury: intramuscular electromyography as a biomarker for functional recovery
经皮脊髓电刺激联合机器人辅助步态训练改善脊髓损伤患者的行动能力和平衡能力：肌内肌电图作为功能恢复的生物标志物
Abdul RashadHe XijingMuhammad Asif
Registered Report 09 March 2026
Article: 245
Neoadjuvant camrelizumab combined with radiotherapy as a chemotherapy-sparing approach for resectable locally advanced esophageal squamous cell carcinoma: a phase II clinical trial (ESOCORT-NIRT)
新辅助卡瑞利珠单抗联合放疗作为可切除局部晚期食管鳞癌的免化疗方案：一项II期临床试验（ESOCORT-NIRT）
Maohui ChenYizhou HuangBin Zheng
Research 09 March 2026
Article: 244
FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy
FLASH放疗在保持抗肿瘤疗效的同时维持全身及组织稳态
Giulia FuriniEduarda Mota da SilvaMargherita Maffei
Research 26 February 2026
Article: 243
fMRI-guided V1-targeted rTMS improves depressive symptoms in adolescents and young adults with bipolar disorder: a double-blind randomized controlled trial
功能磁共振成像引导的V1区靶向重复经颅磁刺激改善青少年及青年双相情感障碍患者的抑郁症状：一项双盲随机对照试验
Xudong ZhaoHetong ZhouMinmin Wang
Research 07 March 2026
Article: 242
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童及青少年精神病学
Impairment of brain short association fibers across clinical stages in amyotrophic lateral sclerosis: a new biomarker mirroring disease progression
肌萎缩侧索硬化症临床各阶段脑短联结纤维受损情况：一种反映疾病进展的新型生物标志物
Nao-Xin HuangZi-Wei CaiHua-Jun Chen
Research 06 March 2026
Article: 241
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
Social frailty and the risk of progression from health to physical, psychological, and cognitive multimorbidity: a prospective multi-cohort study
社会脆弱性与从健康状态进展至身体、心理及认知多病共存状态的风险：一项前瞻性多队列研究
Yaguan ZhouHtet Lin HtunYi Guo
Research 06 March 2026
Article: 240
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学及风险因素的作用
Association between early life constituent-specific PM2.5 exposure and child development and the moderating role of greenness: a nationwide study in China
中国全国范围内早期生命特定成分PM2.5暴露与儿童发育的关联及绿地调节作用的研究
Ruili LiXiaoguo ZhengXiaoning Lei
Research 06 March 2026
Article: 239
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童及青少年精神病学
Intravenous thrombolysis versus standard medical therapy in minor stroke patients with large vessel severe stenosis or occlusion: a systematic review and meta-analysis
静脉溶栓与标准药物治疗轻型卒中合并大血管重度狭窄或闭塞患者的系统综述与荟萃分析
Tianhao ZhangLin TongZhigang Liang
Research 06 March 2026
Article: 238
Long-term risk of offspring type 1 and type 2 diabetes following maternal gestational diabetes mellitus: a nationwide birth cohort study with 10-year follow-up
母亲妊娠期糖尿病后子女患1型和2型糖尿病的长期风险：一项为期10年随访的全国出生队列研究
Joon Ho MoonHan Na JungSung Hee Choi
Research 06 March 2026
Article: 237
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题合集：妊娠期糖尿病的诊断与治疗
Parental income in childhood and health outcomes across age groups: a register-based study from Norway
童年期父母收入与各年龄段健康结局：一项基于挪威登记数据的研究
Bjørn-Atle RemeHans Fredrik SundeJonathan Wörn
Research 06 March 2026
Article: 236
AI-based quality control was associated with improved fetal ultrasound image quality in low-resource settings: a real-world multicenter study from West China
基于人工智能的质量控制可改善低资源环境下胎儿超声图像质量：一项来自中国西部的现实多中心研究
Jianxin ZhaoYao TangYong Huang
Research 06 March 2026
Article: 235
Reply to: Intraoperative use of sodium oxybate to prevent post-operative delirium in older patients undergoing major orthopedic surgery
回复：术中使用羟丁酸钠预防老年患者接受大骨科手术后谵妄
Meiying CuiHang XuePing Zhao
Matters Arising 13 April 2026
Article: 234
Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis
无假设的循环代谢组学评估为肌萎缩侧索硬化症中能量底物可用性的细胞特异性作用提供见解
Elham AlhathliJohnathan Cooper-KnockPamela J. Shaw
Research 06 March 2026
Article: 233
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
Intraoperative use of sodium oxybate to prevent postoperative delirium in older patients undergoing major orthopedic surgery
术中使用羟丁酸钠预防老年患者接受大骨科手术后谵妄
Fu-Shan XueDan-Feng WangXiao-Chun Zheng
Matters Arising 13 April 2026
Article: 232
Statin therapy and stroke risk in patients with hypercholesterolaemia: a population-based longitudinal study using electronic health records in South London
他汀类药物治疗与高胆固醇血症患者卒中风险：一项基于南伦敦电子健康记录的纵向人群研究
Marc DelordAbdel Douiri
Research 05 March 2026
Article: 231
Thermal ablation versus hepatectomy for solitary colorectal liver metastases up to 5 cm: a multicenter target trial emulation on safety, efficacy, and cost-effectiveness
热消融与肝切除术治疗直径达5厘米的孤立性结直肠癌肝转移：一项关于安全性、疗效及成本效益的多中心目标试验模拟研究
Jianming LiLu LiPing Liang
Research 05 March 2026
Article: 230
Why hyperinsulinemia is detrimental to weight loss: insights from type 1 diabetes
为何高胰岛素血症不利于减重：来自1型糖尿病的见解
Stephan MartinKerstin KempfHubert Kolb
Debate 10 April 2026
Article: 229
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减重干预措施及其健康影响
Interventions to prevent and treat multiple long-term conditions and their consequences across the life course: concepts and definitions
预防和治疗多种长期疾病及其在生命周期中后果的干预措施：概念与定义
Miles D. WithamGuruprasad P. AithalThe Multiple Long-Term Conditions Cross-NIHR Collaboration Interventions and Prevention Workstream
Forum 10 April 2026
Article: 228
Effectiveness of nirmatrelvir/ritonavir and molnupiravir on post-COVID diabetes risk among an older adult cohort: a target trial emulation study
奈玛特韦/利托那韦和莫努匹韦对老年人群新冠后糖尿病风险的影响：一项目标试验模拟研究
Zihao GuoYuchen WeiKa Chun Chong
Research 17 March 2026
Article: 227
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与传染病
Iron deficiency and dementia risk: evidence from the Swedish population-based cohort study AMORIS
瑞典基于人群的队列研究AMORIS中铁缺乏与痴呆风险的证据
Mozhu DingAlexandra WennbergKarin Modig
Research 08 April 2026
Article: 226
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Effects of ultrasound-guided stellate ganglion block in poststroke bulbar palsy: a double-blind placebo-controlled trial
超声引导下星状神经节阻滞对脑卒中后球麻痹的影响：一项双盲安慰剂对照试验
Hongji ZengWeihong ZhangXi Zeng
Research 04 March 2026
Article: 225
Dual-utility ctDNA in diffuse large B-cell lymphoma: integrated genotyping unveils minimal residual disease dynamics and subtype-specific clonal evolution
双用途循环肿瘤DNA在弥漫性大B细胞淋巴瘤中的应用：整合基因分型揭示微小残留病灶动态变化及亚型特异性克隆演变
Jin-Hua LiangYi-Fan WuWei Xu
Research 04 March 2026
Article: 224
Risks of non-breast, non-ovarian cancers for BRCA1 and BRCA2pathogenic variant carriers: a prospective cohort study
BRCA1和BRCA2致病性变异携带者患非乳腺、非卵巢癌的风险：一项前瞻性队列研究
Ruotong YangRobert J. MacInnisShuai Li
Research 04 March 2026
Article: 223
Cardiovascular outcomes of intensive blood pressure control in patients with and without metabolic dysfunction-associated fatty liver disease: post hoc analysis of the CRHCP trial
在伴有和不伴有代谢功能障碍相关脂肪性肝病的患者中，强化血压控制的心血管预后：CRHCP试验的事后分析
Songyue LiuYangzhi YinXiaofan Guo
Research 04 March 2026
Article: 222
The role of COPD and inhaled corticosteroids in major adverse cardiovascular events in cardiovascular-kidney-metabolic populations
慢性阻塞性肺疾病和吸入性糖皮质激素在心血管-肾脏-代谢人群主要不良心血管事件中的作用
Anne E. IoannidesEmily L. GraulJennifer K. Quint
Research 04 March 2026
Article: 221
Ethnic differences in the burden of cardiovascular disease risk factors among adult residents of London: the TOGETHER study
伦敦成年居民心血管疾病风险因素负担的种族差异：TOGETHER研究
Fotios BarkasMalo DirouKausik K. Ray
Research 03 March 2026
Article: 220
Development of a novel prognostic assessment tool for recurrent respiratory papillomatosis
复发性呼吸道乳头瘤病新型预后评估工具的开发
Satoshi YamadaTaro IkegamiKiyoshi Misawa
Research 16 April 2026
Article: 219
Response to: Matters Arising in relation to “Evaluating agreement between individual nutrition randomised controlled trials and cohort studies – a meta-epidemiological study”
针对“评估个体营养随机对照试验与队列研究之间的一致性——一项元流行病学研究”的相关问题探讨
Julia StadelmaierGina BantleLukas Schwingshackl
Matters Arising 09 April 2026
Article: 218
Concordance between nutritional cohorts and randomized trials: biological confirmation or statistical consequence? A re-analysis of Stadelmaier et al.
营养队列研究与随机试验之间的一致性：生物学证实还是统计学结果？对Stadelmaier等人的研究再分析
Matthew CalkinsIsaac NúñezAdrian Soto-Mota
Matters Arising 09 April 2026
Article: 217
Multimorbidity patterns and 15-year trajectories of physical performance: a population-based study
多病共存模式与15年身体机能变化轨迹：一项基于人群的研究
Francesco PalmeseDavide Liborio VetranoFederico Triolo
Research 25 March 2026
Article: 216
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
The need for clinical studies assessing whether weight loss improves functional outcome after stroke in diabetes
评估减肥是否改善糖尿病患者中风后功能预后的临床研究需求
Ellen VercalsterenMichael V. MazyaCesare Patrone
Debate 24 March 2026
Article: 215
Targeting STE20-type kinase MST3 improves metabolic dysfunction-associated steatohepatitis without affecting hepatocellular carcinoma development in mice
靶向STE20型激酶MST3可改善小鼠代谢功能障碍相关脂肪性肝炎，且不影响肝细胞癌的发展
Jingjing ZhangXiangdong GongyeMargit Mahlapuu
Research 24 March 2026
Article: 214
Multimorbidity patterns and the subsequent risk of albuminuria: findings from the Stockholm Creatinine Measurements (SCREAM) project
多病共存模式与后续白蛋白尿风险：来自斯德哥尔摩肌酐测量（SCREAM）项目的研究结果
Giorgi BeridzePatrick B. MarkJuan-Jesus Carrero
Research 24 March 2026
Article: 213
Myeloid-derived immunosuppression of chimeric antigen receptor T cells in the neuronal microenvironment of glioblastoma
胶质母细胞瘤神经元微环境中髓系来源的免疫抑制对嵌合抗原受体T细胞的影响
Junyi ZhangJasmin von EhrYahaya A. Yabo
Research 13 March 2026
Article: 212
Associations of genetically predicted interleukin-6 and tumor necrosis factor signaling pathways with mortality among persons with colorectal cancer: a two-sample Mendelian randomization
基因预测的白细胞介素-6和肿瘤坏死因子信号通路与结直肠癌患者死亡率之间的关联：一项双样本孟德尔随机化研究
Martina BoukaKatharina NimptschTobias Pischon
Research 06 March 2026
Article: 211
Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS
血管生成素样系统紊乱将肌萎缩侧索硬化症中的脂质稳态与下丘脑功能障碍关联起来
Sruthi Sankari KrishnamurthyAdriana Zardini BuzattoFrancesco Roselli
Research 03 March 2026
Article: 210
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
Day+30 detection of minimal residual FLT3-ITD by high-sensitivity PCR-NGS predicts relapse risk and guides post-transplant maintenance in AML
移植后第30天通过高灵敏度PCR-NGS检测微小残留FLT3-ITD可预测急性髓系白血病（AML）复发风险并指导移植后维持治疗
Shan JiangDan FengErlie Jiang
Research 03 March 2026
Article: 209
Early childhood weight gain and alanine aminotransferase at age 8: an adjunct study of the Japan Environment and Children’s Study
幼儿期体重增长与8岁时丙氨酸氨基转移酶水平：日本环境与儿童研究的一项辅助研究
Naw Awn J-PKeiko YamasakiNarufumi Suganuma
Research 03 March 2026
Article: 208
Anti-CD19 chimeric antigen receptor T-cell therapy for relapsed or refractory Philadelphia chromosome-positive B cell acute lymphoblastic leukemia: a multicenter retrospective study
抗CD19嵌合抗原受体T细胞疗法治疗复发或难治性费城染色体阳性B细胞急性淋巴细胞白血病：一项多中心回顾性研究
Jinglei YuFengmei SongGuoqing Wei
Research 03 March 2026
Article: 207
Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics
通过单细胞和空间转录组学鉴定人类卵巢皮质中的冷敏感生态位及可靶向的FOS/AP-1程序
Fanghao GuoDi SunWen Li
Research 03 March 2026
Article: 206
Neoadjuvant camrelizumab combined with metronomic chemotherapy in patients with advanced esophageal squamous cell carcinoma: a pilot randomized phase 2 trial
卡瑞利珠单抗联合节拍化疗新辅助治疗晚期食管鳞状细胞癌：一项随机2期初步试验
Zhiming ChenWenshuai LiJie Liu
Research 03 March 2026
Article: 205
Part of 1 collection:Clinical trials for gastrointestinal cancer
所属专题合集：胃肠道癌症临床试验
Vericiguat for endothelial dysfunction and CRT response in non-responders: the VERCET prospective observational study
维利西呱治疗无反应者的内皮功能障碍和心脏再同步化治疗（CRT）反应：VERCET前瞻性观察研究
Celestino SarduLudovica Vittoria MarfellaRaffaele Marfella
Research 03 March 2026
Article: 204
Part of 1 collection:Cardiomyopathy and cardiac arrhythmias
所属专题合集：心肌病和心律失常
Assessment of antibody responses to Anopheles SG6-P1 and Aedes N-term 34kDa salivary peptides: a randomised human-challenge trial of controlled exposures to vector bites
评估针对按蚊SG6-P1和伊蚊N端34 kDa唾液肽的抗体反应：一项对媒介叮咬进行可控暴露的随机人体挑战试验
Victor ChaumeauEllen A. KearneyFreya J. I. Fowkes
Research 02 March 2026
Article: 203
Is random biopsy necessary for normal esophageal mucosa during chromoendoscopy? Evidence from a population-based cohort study
在色素内镜检查过程中，对于正常食管黏膜是否有必要进行随机活检？一项基于人群的队列研究证据
Wenlei YangMengfei LiuYang Ke
Research 02 March 2026
Article: 202
Sinusoidal cell–derived biomarker scores predict diagnosis and prognosis in chronic liver disease
窦状隙细胞来源的生物标志物评分可预测慢性肝病的诊断和预后
Sergi Guixé-MuntetAnabel Fernández-IglesiasJordi Gracia-Sancho
Research 28 February 2026
Article: 201
Anticholinergic drug burden and incident cardiovascular events: a population-based study
抗胆碱能药物负担与新发心血管事件：一项基于人群的研究
Nanbo ZhuMaria EriksdotterHong Xu
Research 28 February 2026
Article: 200
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Sensitive periods of BMI change from childhood to adulthood on subclinical cardiovascular outcomes: a 36-year prospective cohort study
从儿童期到成年期体重指数（BMI）变化对亚临床心血管结局影响的敏感期：一项为期36年的前瞻性队列研究
Hui YangTongshuai GuoJianjun Mu
Research 27 February 2026
Article: 199
Feasibility and preliminary efficacy of an art-making program to manage fear of cancer recurrence (AM-I-FCR) in lung cancer patients: a randomized controlled pilot study
艺术创作项目（AM-I-FCR）管理肺癌患者对癌症复发恐惧的可行性与初步疗效：一项随机对照试点研究
Jialing LinZhixuan KangFeifei Huang
Research 27 February 2026
Article: 198
Unveiling disparities in lung cancer care: a joint spatio-temporal analysis of multidisciplinary meeting presentation, supportive care screening, and diagnostic timeliness in Victoria
揭示肺癌诊疗差异：维多利亚州多学科会诊展示、支持性护理筛查及诊断及时性的联合时空分析
Getayeneh Antehunegn TesemaRob G. StirlingArul Earnest
Research 27 February 2026
Article: 197
Transcriptome-based high-frequency recurrence index predicts frequent recurrence in non-muscle-invasive bladder cancer after Bacillus Calmette-Guérin therapy
基于转录组的高频复发指数可预测卡介苗治疗后非肌层浸润性膀胱癌的频繁复发情况
Seung-Woo BaekYoung Joon ByunSeok Joong Yun
Research 27 February 2026
Article: 196
Life-course influence of birthweight and subsequent pathways on healthy aging: a Mendelian randomization study
出生体重对健康老龄化的终身影响及后续途径：一项孟德尔随机化研究
Lijie KongChun DouTiange Wang
Research 25 February 2026
Article: 195
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Routine inflammatory indices modify clonal hematopoiesis-related prognostic risk in patients undergoing percutaneous coronary intervention: a real-world cohort study
常规炎症指标改变接受经皮冠状动脉介入治疗患者的克隆性造血相关预后风险：一项现实队列研究
Xuxiang ShenYing SongXiangfeng Lu
Research 25 February 2026
Article: 194
Health experiences and outcomes of autistic and non-autistic adults with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder
自闭症和非自闭症成年孤独症患者及非孤独症患者中患有高迁移率埃勒斯-丹洛斯综合征和高迁移率谱系障碍者的健康体验和预后
Catherine J. CromptonThemis N. EfthimiouKathryn M. Berg
Research 25 February 2026
Article: 193
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Effects of non-pharmacological interventions on sleep quality in older adults: a systematic review and network meta-analysis of randomized controlled trials
非药物干预措施对老年人睡眠质量影响：基于随机对照试验的系统综述和网络荟萃分析
Jia SongHeng DongShangfeng Tang
Research 25 February 2026
Article: 192
Cortical excitability mapping stratifies neurobiological subtypes of schizophrenia with genetic and molecular signatures
皮质兴奋性映射对具有遗传和分子特征的精神分裂症神经生物学亚型进行分层
Sixuan GuoYu ZhaoQiyong Gong
Research 25 February 2026
Article: 191
Minimum 18-week chemotherapy improves survival in locally advanced rectal cancer after neoadjuvant radiotherapy: a post hoc analysis of the STELLAR trial
新辅助放疗后局部晚期直肠癌患者接受至少18周化疗可改善生存率：STELLAR试验的事后分析
Tongzhen XuHuiying MaJing Jin
Research 25 February 2026
Article: 190
Helminth coinfections mitigate clinical, parasitological, and immune outcomes in Mozambican children with malaria
在莫桑比克患疟疾的儿童中，蠕虫共感染可减轻临床、寄生虫学和免疫学转归
Inocência CuambaRebeca SantanoCarlota Dobaño
Research 31 March 2026
Article: 189
Effectiveness of group-based art interventions for late-life depression: a systematic review and meta-analysis of randomized controlled trials
团体艺术干预对老年抑郁症的疗效：一项针对随机对照试验的系统综述和荟萃分析
Mohamad AzhdarlooRaziyeh AtaeiAbouzar Nazari
Research 24 February 2026
Article: 188
The associations of consultant sex on herding‑like prescribing behaviour: evidence from a web-based experiment with female primary care physicians in England
顾问性别对从众式处方行为的影响：来自一项针对英格兰女性初级保健医生的网络实验的证据
Sandro Tiziano StoffelMatthias SchwenkglenksBerna Cennet Özdemir
Research 24 February 2026
Article: 187
Tricarboxylic acid cycle metabolite index predicts adverse outcomes in acute myocardial infarction patients
三羧酸循环代谢物指数预测急性心肌梗死患者的不良预后
Ye WangPengyan WuBo Yu
Research 24 February 2026
Article: 186
Targeting cancer stem cells predicts response and reverses chemoresistance in ascites-derived ovarian cancer organoids
靶向癌症干细胞可预测腹水来源的卵巢癌类器官的反应并逆转化疗耐药性
Xiaoli ZhangWen ZhangHuiqin Guo
Research 24 February 2026
Article: 185
Neural vulnerability to stress in adolescents: a longitudinal study using polyconnectomic scoring of depression risk
青少年神经对压力的易感性：一项使用抑郁风险多连接组评分进行的纵向研究
Yuan LiuMeijuan LiJie Li
Research 24 February 2026
Article: 184
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Classification of ALS molecular subtypes: a literature review on machine learning applications and their clinical value
肌萎缩侧索硬化症分子亚型分类：机器学习应用及其临床价值的文献综述
John K. JammalEsteban A. GomezAlfredo Iacoangeli
Review 23 February 2026
Article: 183
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
Can we protect refugee children from mental health problems?— a scoping review of modifiable factors to inform preventive interventions
我们能否保护难民儿童免受心理健康问题困扰？——一项旨在为预防性干预提供信息的可改变因素的范围性综述
Rita GonçalvesM J MarquesSónia Dias
Research 23 February 2026
Article: 182
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
The Trial Bank initiative to promote trustworthy living evidence for medication safety (PROMISE) of children: design and pilot validation
促进儿童用药安全可信实时证据（PROMISE）的试验库计划：设计与初步验证
Chang XuSuhail A. DoiPROMISE Collaborative Research Network
Research 21 February 2026
Article: 181
Is liquid biopsy a cost-effective method to diagnose Burkitt Lymphoma in children and young adults? A health economic evaluation in Tanzania
液体活检是否为诊断坦桑尼亚儿童和青年成人伯基特淋巴瘤的一种具有成本效益的方法？一项卫生经济学评估
Jingjing JiangLiz MorrellAI-REAL Consortium
Research 21 February 2026
Article: 180
The influence of immunohistochemistry-based subtypes on overall survival in breast cancer spine metastases: a systematic review and meta-analysis
基于免疫组织化学的亚型对乳腺癌脊柱转移总生存期的影响：一项系统综述和荟萃分析
Fon-Yih TsuangYun-Heng LiChung Liang Chai
Research 21 February 2026
Article: 179
Prenatal exposure to maternal asthma and asthma medication and neurodevelopmental outcomes: a population cohort study of 179,024 children
产前接触母体哮喘及哮喘药物与神经发育结局的关系：一项针对179,024例儿童的人群队列研究
Lama A. ShakhshirSarjit SinghMichael Fleming
Research 20 February 2026
Article: 178
First-in-human phase 1/2a study of T3011, an oncolytic HSV expressing IL-12 and PD-1 antibody, administered via intratumoral (IT) injection as monotherapy in advanced solid tumors, including recurrent or metastatic HNSCC
T3011（一种表达IL-12和PD-1抗体的溶瘤性单纯疱疹病毒）首次人体1/2a期研究：通过瘤内（IT）注射作为单一疗法治疗包括复发或转移性头颈部鳞状细胞癌在内的晚期实体瘤
Dongmei JiWenmin FuXichun Hu
Research 20 February 2026
Article: 177
Expanding access to cerebrovascular imaging with routine MRI for pre-surgical assessment of intracranial tumor patients: an AI model development and multi-center validation study
利用常规MRI扩大脑血管成像在颅内肿瘤患者术前评估中的应用范围：一项人工智能模型开发与多中心验证研究
Chaoyue ChenZhouyang HuangJianguo Xu
Research 20 February 2026
Article: 176
Changing landscape of physical fitness and urban–rural inequalities: evidence from 1.2 million children and adolescents over 20 years of urbanization
20年城市化进程中120万例儿童和青少年体质健康状况及城乡差异的变化
Shan CaiJiaxin LiYi Song
Research 19 February 2026
Article: 175
Efficacy and safety of anti-prediabetic drugs in patients with prediabetes: a Bayesian network meta-analysis
抗糖尿病前期药物在糖尿病前期患者中的疗效和安全性：一项贝叶斯网状荟萃分析
Yike WuZihan WangGuo Ma
Research 19 February 2026
Article: 174
Clonal haematopoiesis of indeterminate potential and risk of incident psychiatric disorders
Yuefeng YuChenyi WanNingjian Wang
意义未明的克隆性造血与新发精神障碍风险
Research 18 February 2026
Article: 173
Spatial characterization of intrahepatic fat deposition across steatotic liver disease subcategories: a multicenter study
脂肪性肝病各亚类中肝内脂肪沉积的空间特征：一项多中心研究
Yan-Ci ZhaoMin WangFeng Chen
Research 18 February 2026
Article: 172
Pregnancy outcomes among medically complex populations with high risk of pregnancy mortality in Virginia: a retrospective observational study
弗吉尼亚州妊娠死亡高风险医学复杂人群的妊娠结局：一项回顾性观察研究
Michael J. GreenLauren G. AndersonJonas J. Swartz
Research 18 February 2026
Article: 171
Maternal amino acid metabolites during pregnancy and preterm birth: results from two prospective cohort studies
孕期母体氨基酸代谢物与早产的关系：两项前瞻性队列研究的结果
Jingnan ChenYidan DongJu-Sheng Zheng
Research 18 February 2026
Article: 170
Correction: Trajectory of the body weight after drug discontinuation in the treatment of anti-obesity medications
更正：停用抗肥胖药物后体重的变化轨迹
Han WuWenjia YangLinong Ji
Correction 25 March 2026
Article: 169
Physical activity patterns and cardiovascular disease risk in adults with overweight or obesity: a prospective cohort study
超重或肥胖成人身体活动模式与心血管疾病风险：一项前瞻性队列研究
Kai MuYanan QiaoBo Xi
Research 16 February 2026
Article: 168
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减肥干预措施及其对健康的影响
Maternal migraine and offspring ADHD: triangulating the evidence
母亲偏头痛与后代多动症（ADHD）：多方证据综合分析
Yaxin LuoChristina DardaniEvie Stergiakouli
Research 14 February 2026
Article: 167
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
An autonomous siRNA delivery system targeting NLRP3: implications in Parkinson’s disease
靶向NLRP3的自主性小干扰RNA（siRNA）递送系统：在帕金森病中的潜在意义
Lishan LinZhizong LiZhong Pei
Research 12 February 2026
Article: 166
Lay descriptions of painful temporomandibular disorders—an international consensus proposal for Global Burden of Disease estimates
颞下颌关节紊乱病疼痛的通俗描述——全球疾病负担评估的国际共识提案
A. LövgrenP. LivP. Svensson
Research 17 March 2026
Article: 165
Association of soluble tumor necrosis factor receptor 1 with tau pathology, brain atrophy, and cognitive decline: a longitudinal study
可溶性肿瘤坏死因子受体1与tau蛋白病变、脑萎缩及认知功能下降的关联：一项纵向研究
Yutong ZhangLulu SunAlzheimer’s Disease Neuroimaging Initiative
Research 11 February 2026
Article: 164
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Particulate matter and respiratory health in middle-aged and older adults: disentangling size-fractionated and constituent-specific effects under China’s clean-air policies
颗粒物与中老年人呼吸系统健康的关系：厘清中国净化空气政策下不同粒径及成分的特定影响
Yujing ChenZhaoyan LiuYu-ming Chen
Research 11 February 2026
Article: 163
Part of 1 collection:Climate change and human health
所属专题合集：气候变化与人类健康
Clinical impact and cost-effectiveness of vaccinating infants and adolescents against invasive meningococcal B disease in the Netherlands
荷兰为婴儿和青少年接种针对侵袭性脑膜炎球菌B病的疫苗的临床影响和成本效益
Thomas OttenMirjam KnolAnneke Steens
Research 10 February 2026
Article: 162
Association between trajectories of sleep quality and postpartum depression: a group-based trajectory model and computer-simulated network analysis
睡眠质量轨迹与产后抑郁之间的关联：基于组别的轨迹模型和计算机模拟网络分析
Xiaoxiao MeiJinzhou YuZengjie Ye
Research 10 February 2026
Article: 161
Part of 1 collection:Sleep and mental health
所属专题合集：睡眠与心理健康
Understanding Japan’s mortality advantage: a comparison of mortality in independent and dependent older adults in Japan and Sweden
解读日本在死亡率方面的优势：日本与瑞典独立生活及依赖他人生活老年人的死亡率比较
Shunsuke MurataMarcus EbelingKarin Modig
Research 23 March 2026
Article: 160
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学及风险因素的作用
The Young Adult Sleep model: an evolving causal loop diagram of mental health dynamics
青年睡眠模型：心理健康动态演变的因果环路图
Jeroen F. UlemanRushd F. M. Al-ShamaNaja Hulvej Rod
Research 16 March 2026
Article: 159
Part of 1 collection:Sleep and mental health
所属专题合集：睡眠与心理健康
Oncostatin-M ligand-based CAR-T therapy displays robust anti-tumor activity against osteosarcoma
基于抑瘤素M配体的CAR-T疗法对骨肉瘤显示出强大的抗肿瘤活性
Daniel FeinbergVinayak UppinReshmi Parameswaran
Research 17 March 2026
Article: 158
Antimicrobial catheters coated with poly-L-lysine for the prevention of bacteriuria in adults requiring short-term catheterization: a multicenter randomized controlled trial
涂有聚-L-赖氨酸的抗菌导管预防短期导尿成人患者菌尿症：一项多中心随机对照试验
Xinfei LiJun LiuKai Zhang
Research 09 February 2026
Article: 157
Penpulimab in combination with lenalidomide and R-GemOx regimen (R2-GemOx-PD1i) in relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm, phase 2 trial
派安普利单抗联合来那度胺和R-GemOx方案（R2-GemOx-PD1i）治疗复发或难治性弥漫性大B细胞淋巴瘤：一项多中心、单臂、2期试验
Jin-Hua LiangTong-Yao XingWei Xu
Research 09 February 2026
Article: 156
Digital twin brain reveals state-specific stimulation targets for abnormal brain dynamics in tinnitus
数字孪生大脑揭示耳鸣异常脑动力学状态特异性刺激靶点
Jiaqi ZhangShuting HanTianzi Jiang
Research 10 February 2026
Article: 155
The case for mandatory reporting to enable targets for healthy and environmentally sustainable food: means, motive and opportunity
强制报告实现健康且环境可持续食物目标的理由：方法、动机和机会
Rachel PecheyLauren BandySusan A. Jebb
Debate 10 February 2026
Article: 154
Genetic insights into radiomic and proteomic changes under β1-blockers treatment in hypertensive heart disease and hypertrophic cardiomyopathy
β1受体阻滞剂治疗高血压性心脏病和肥厚型心肌病时放射组学和蛋白质组学变化的遗传学见解
Zhe ChenYifan TangKai Xie
Research 09 February 2026
Article: 153
Part of 1 collection:Cardiomyopathy and cardiac arrhythmias
所属专题合集：心肌病与心律失常
Optimizing drug-resistant tuberculosis diagnosis: cost-effectiveness of rapid molecular and phenotypic assays in South Africa
优化耐药结核病诊断：南非快速分子和表型检测方法的成本效益分析
Ginenus FekaduTadesse TolossaWai Kit Ming
Research 09 February 2026
Article: 152
Maternal smoking based on pre-birth health examination and risk of neurodevelopmental disorders in offspring: insights from a Korean mother–child cohort
基于产前健康检查探讨母亲吸烟与后代神经发育障碍风险的关系：来自韩国母婴队列研究的见解
Chan Soon ParkMoonyoung JangJun-Bean Park
Research 11 March 2026
Article: 151
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Effects of ablation versus drug therapy on clinical outcomes and quality of life by frailty status in atrial fibrillation: a post hoc analysis of the CABANA trial
根据衰弱状态分析消融术与药物治疗对心房颤动患者临床预后和生活质量的影响：CABANA试验的事后分析
Lili WangYanguang LiYunlong Wang
Research 07 February 2026
Article: 150
Part of 1 collection:Cardiomyopathy and cardiac arrhythmias
所属专题合集：心肌病与心律失常
Quantifying lifetime risk for 1,401 infectious diseases across the diabetes spectrum using a Bayesian approach
采用贝叶斯方法量化糖尿病全病程中1401种传染病的终生风险
Boomer B. OlsenMartin Tristani-FirouziEdgar Javier Hernandez
Research 07 February 2026
Article: 149
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与传染病
Risk assessment of asthma and allergic rhinitis in atopic dermatitis patients treated with biologics and JAK inhibitors: a systematic review and network meta-analysis of randomized controlled trials
对接受生物制剂和JAK抑制剂治疗的特应性皮炎患者罹患哮喘和过敏性鼻炎的风险评估：一项针对随机对照试验的系统综述和网络荟萃分析
Liling ZengTong ZhouJing Li
Research 07 February 2026
Article: 148
Preclinical activity of brincidofovir in peripheral T-cell and NK/T-cell lymphoma
布林西多福韦（brincidofovir）在外周T细胞和NK/T细胞淋巴瘤中的临床前活性
Jason Yongsheng ChanElizabeth Chun Yong LeeChoon Kiat Ong
Research 06 February 2026
Article: 147
Genetic risk factors modulate the association between physical activity and colorectal cancer
遗传风险因素调节身体活动与结直肠癌之间的关联
Anita R. PeoplesMireia Obón-SantacanaVictor Moreno
Research 05 February 2026
Article: 146
A neuroimaging biomarker for disease staging in clinically diagnosed Alzheimer’s disease
临床诊断阿尔茨海默病的疾病分期神经影像学标志物
Zhuangzhuang LiShaozhen YanYong Liu
Research 05 February 2026
Article: 145
Association of GLP-1 receptor agonists with herpes risks in diabetes mellitus: a target trial emulation
胰高血糖素样肽-1（GLP-1）受体激动剂与糖尿病中疱疹风险的关联：一项目标试验模拟研究
Chi-Hsien HuangI-Hui ChiangJames Cheng-Chung Wei
Research 31 December 2025
Article: 144
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与感染性疾病
Neoadjuvant immunochemotherapy plus thymalfasin in locally advanced gastric cancer: a prospective clinical trial
局部晚期胃癌联合胸腺肽的新辅助免疫化疗：一项前瞻性临床试验
Hao XuFengyuan LiZekuan Xu
Research 26 February 2026
Article: 143
Part of 1 collection:Clinical trials for gastrointestinal cancer
所属专题合集：胃肠道癌症的临床试验
Detection of sequelae from acute meningitis during clinical review by a healthcare provider: a systematic review and meta-analysis
临床医生在临床复查中检测急性脑膜炎后遗症：一项系统综述和荟萃分析
Luisa F. AlvizCarla Y. KimKiran T. Thakur
Research 28 February 2026
Article: 142
Part of 1 collection:Acute meningitis: a collection of systematic reviews
所属专题合集：急性脑膜炎：系统综述合集
ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics
ISG15驱动的免疫调节与乳腺癌转移中的肿瘤进展：来自单细胞和空间转录组学的见解
Hua ShaoHanlu TangYongqing Xu
Research 04 February 2026
Article: 141
Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk
评估家族史和多基因风险评分对心代谢疾病风险的影响
Ebuka OnyenobiKnightess OyiboSally N. Adebamowo
Research 03 February 2026
Article: 140
Social networking site use, depressive and anxiety symptoms in adolescents: evidence from a longitudinal cohort study (SCAMP)
社交网站使用与青少年抑郁和焦虑症状：来自纵向队列研究（SCAMP）的证据
Chen ShenBraulio M. Girela-SerranoMireille B. Toledano
Research 03 February 2026
Article: 139
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Early gestational prediction of spontaneous preterm birth using a validated three-protein serum biomarker panel
使用经验证的三蛋白血清生物标志物组合进行早孕期自发性早产预测
Qiong LuoJuan WeiXuefeng B. Ling
Research 02 February 2026
Article: 138
Household cannabis cessation and adolescent mental health outcomes in a prospective cohort study
一项前瞻性队列研究中家庭大麻戒断与青少年心理健康预后的关系
Ming WangYixiang XuFei Li
Research 02 February 2026
Article: 137
Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies
所属专题合集：精神活性物质：娱乐性药物重新利用为新型疗法
Objective assessment of long-term impact of COVID-19 on multiple sensory functions
客观评估新冠肺炎对多种感觉功能的长期影响
Ahmad OdehVeronica L. FormanekKai Zhao
Research 27 February 2026
Article: 136
Detection of hearing loss by formal audiological testing after acute infectious meningitis: a global systematic review and meta-analysis
急性感染性脑膜炎后通过正式听力检测诊断听力损失：一项全球系统综述和荟萃分析
Luisa F. AlvizCarla Y. KimKiran T. Thakur
Review 28 February 2026
Article: 135
Part of 1 collection: Acute meningitis: a collection of systematic reviews
所属专题合集：急性脑膜炎：系统综述合集
Serological evidence of substantial respiratory syncytial virus infection burden among older adults residing in Swedish long-term care facilities
血清学证据表明，居住在瑞典长期护理机构中的老年人存在沉重的呼吸道合胞病毒感染负担
Preeti MoarChristoffer GranvikMattias N. E. Forsell
Research 24 February 2026
Article: 134
Association of parental education with offspring psychiatric diagnoses, violent crimes, and suicidal behavior: a nationwide Swedish quasi-experimental study
父母受教育程度与后代精神疾病诊断、暴力犯罪和自杀行为之间的关联：一项瑞典全国范围的准实验研究
Mengping ZhouHenrik LarssonErik Pettersson
Research 26 February 2026
Article: 133
Discriminative performance of externally validated dementia risk prediction models: a systematic review and meta-analysis
外部验证的痴呆风险预测模型的鉴别性能：一项系统综述和荟萃分析
Blossom C. M. StephanJacob BrainMario Siervo
Research 02 February 2026
Article: 132
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian cancer: a phase 3, double-blind, parallel group, randomized controlled pilot study
静脉注射大剂量硒预防铂敏感复发性卵巢癌化疗所致周围神经病变的有效性和安全性：一项3期、双盲、平行组、随机对照试点研究
Ga Won YimKyung Hee HanHee Seung Kim
Research 02 February 2026
Article: 131
Time for change in implementation research and practice
实施研究和实践中变革的时机已到
Mike EnglishJacob McKnightSebastian Fuller
Debate 02 February 2026
Article: 130
CardioMetAge estimates cardiometabolic aging and predicts disease outcomes
CardioMetAge可评估心脏代谢年龄并预测疾病结局
Yucan LiXinming XuKelin Xu
Research 31 January 2026
Article: 129
Disproportionate climate burden of rising temperatures on low birth weight in Pakistan
气温上升给巴基斯坦低出生体重儿带来的不成比例的气候负担
Syeda H. FatimaCorey J. A. BradshawZohra S. Lassi
Research 31 January 2026
Article: 128
Part of 1 collection: Climate change and human health
所属专题：气候变化与人类健康
Enhancing oncolytic virotherapy with a tri-specific T-cell engager targeting CD3ε, EpCaM, and 4-1BB: preclinical evaluation and implications for cancer immunotherapy
利用靶向CD3ε、EpCaM和4-1BB的三特异性T细胞衔接器增强溶瘤病毒疗法：临床前评估及对癌症免疫疗法的启示
Zhongyi DongHaoyu ZhangZizhen Zhang
Research 30 January 2026
Article: 127
Targeting BCL-XL for degradation synergizes with gemcitabine against cholangiocarcinoma
靶向降解BCL-XL与吉西他滨联用对胆管癌具有协同治疗作用
Qinghua ZengYan ZhangYonghan He
Research 30 January 2026
Article: 126
Association of DNA methylation with hypertension and blood pressure: a 7-year longitudinal study from KORA F4/FF4
DNA甲基化与高血压及血压的关联：来自KORA F4/FF4的7年纵向研究
Liye LaiAngelina Shin Yee JongMelanie Waldenberger
Research 04 February 2026
Article: 125
Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis
精神活性物质使用与泛癌症的共享遗传结构：来自大规模全基因组跨性状分析的见解
Jiahang SongPengzhu LiOlivier Gires
Research 05 February 2026
Article: 124
Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies
所属专题：精神活性物质：作为新型疗法的娱乐性药物再利用
Intrauterine exposure to maternal diabetes and the risk of developing epilepsy in children: a national cohort study of 2.3 million children
宫内暴露于母体糖尿病与儿童患癫痫风险的关系：一项针对230万儿童的全国队列研究
Muhammad Zakir HossinMartina PerssonNeda Razaz
Research 14 February 2026
Article: 123
ADHD and adherence to antihypertensive medication treatment: a multinational cohort study
多动症与坚持抗高血压药物治疗的关系：一项多国队列研究
Honghui YaoYiling ZhouZheng Chang
Research 20 February 2026
Article: 122
How effective is rejoining a long-term weight loss program? The 5- and 10-year MRI-assessed Follow Interventions Trial (FIT) project
重新加入长期减肥计划的效果如何？5年和10年磁共振成像评估的随访干预试验（FIT）项目
Hadar KleinDafna PachterIris Shai
Research 30 January 2026
Article: 121
Part of 1 collection: Weight loss interventions and their health impacts
所属专题：减肥干预措施及其对健康的影响
Correction: Brain state dynamics and working memory in patients with schizophrenia and unaffected siblings
更正：精神分裂症患者及其未受影响兄弟姐妹的脑状态动态与工作记忆
Feiwen WangJie YangLena Palaniyappan
Correction 20 February 2026
Article: 120
Ocular light and optical radiation exposure as a modifiable environmental determinant of health: expert consensus on research gaps and priorities
作为可改变的环境健康决定因素的眼睛光暴露和光学辐射暴露：关于研究空白和优先事项的专家共识
Manuel SpitschanAnna M. BillerJohannes Zauner
Guideline 29 January 2026
Article: 119
Dietary patterns and neuropsychological function in adolescents: a cross-sectional and longitudinal study
青少年饮食模式与神经心理功能：一项横断面和纵向研究
Alexios ManidisNicolas Ayala-AldanaJordi Julvez
Research 29 January 2026
Article: 118
Part of 1 collection: Child and adolescent psychiatry
所属专题：儿童与青少年精神病学
Factors impacting the delivery of contextualized care in serious illness: a focus group study with healthcare professionals
影响危重症患者情境化护理实施的因素：一项针对医疗保健专业人员的焦点小组研究
Linda ModderkolkYvonne SchoonAnne B. Wichmann
Research 29 January 2026
Article: 117
Part of 1 collection: Palliative care and medicine
所属专题：姑息治疗与医学
Early interventions for first onset of symptoms of mental health conditions: an umbrella review of systematic reviews
针对心理健康问题首次出现症状的早期干预措施：一项系统综述的伞式评价
Jasmine LeePhoebe BarnettSonia Johnson
Research 29 January 2026
Article: 116
Harmonic patterns embedded in ictal EEG signals in focal epilepsy: new insight into the epileptogenic zone
局灶性癫痫发作间期脑电图信号中嵌入的谐波模式：对致痫区的新见解
Lingli HuLingqi YeShuang Wang
Research 28 January 2026
Article: 115
Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology
所属专题合集：癫痫：发作预防、治疗和流行病学
Effects of aerobic or resistance exercise on sleep and cancer-related fatigue in patients with breast cancer during or after neoadjuvant chemotherapy: a 3-arm randomized controlled trial
有氧运动或抗阻运动对新辅助化疗期间或之后乳腺癌患者睡眠和癌症相关疲劳的影响：一项三臂随机对照试验
Alexander HaussmannMartina E. SchmidtKaren Steindorf
Research 28 January 2026
Article: 114
Neutrophil methylmalonic acid promotes microthrombus formation and adverse cardiac remodeling post-myocardial infarction through activating IL-6 signaling pathway-mediated NETosis
中性粒细胞甲基丙二酸通过激活IL-6信号通路介导的中性粒细胞胞外诱捕网形成（NETosis），促进心肌梗死后微血栓形成和不良心脏重构
Yige LiuJiaxin WangShaohong Fang
Research 28 January 2026
Article: 113
Statistical approaches to analyse the combined effect of seven air pollutants and breast cancer risk: a case–control study nested in the French E3N-Generations cohort
分析七种空气污染物联合作用与乳腺癌风险关系的统计方法：一项嵌套于法国E3N-Generations队列的病例对照研究
Camille GiampiccoloBéatrice FerversAmina Amadou
Research 28 January 2026
Article: 112
Part of 1 collection: Carcinogens and human health
所属专题合集：致癌物与人类健康
Is behaviour change communication guidance for general practice healthcare professionals evidence based? A systematic review
针对全科医疗保健专业人员的行为改变沟通指导是否具有循证依据？一项系统综述
Anika Schwarze-ChintapatlaJonathan Livingstone-BanksCharlotte Albury
Research 16 February 2026
Article: 111
Patient-centred postpartum care provision: virtual delivery, tiered escalation, and tensions between efficiency, preference, and clinical concern
以患者为中心的产后护理服务提供：虚拟服务模式、分级转诊机制，以及效率、患者偏好与临床关切之间的矛盾
Sergio A. SilverioJulia R. B. BrownEmma L. Duncan
Research 24 February 2026
Article: 110
Ethical dilemmas in climate change and healthcare delivery: a cross-sectional survey of US patient perspectives
气候变化与医疗服务中的伦理困境：一项针对美国患者观点的横断面调查
Andrew HantelEmily SenayGregory A. Abel
Research 27 January 2026
Article: 109
Part of 1 collection: Climate change and human health
所属专题：气候变化与人类健康
Inetetamab plus camrelizumab and utidelone for pretreated HER2-positive advanced breast cancer: a prospective, single-arm, phase 2 study
伊尼妥单抗联合卡瑞利珠单抗和优替德隆治疗既往接受过治疗的HER2阳性晚期乳腺癌：一项前瞻性、单臂、2期研究
Huimin LvTao SunMin Yan
Research 27 January 2026
Article: 108
Potential of earlier primary care health checks for prevention of cardiovascular events in younger age groups: population-based study in the United Kingdom
早期初级保健健康检查对预防年轻人群心血管事件的潜力：英国一项基于人群的研究
Catherine A. ScottLinxin LiPeter M. Rothwell
Research 24 January 2026
Article: 107
Comparative effects of salt substitutes on blood pressure, cardiovascular events and mortality: a systematic review and network meta-analysis
盐替代品对血压、心血管事件和死亡率影响的比较：一项系统综述和网络荟萃分析
Honghao LaiGihad NesrallahBradley C. Johnston
Research 23 January 2026
Article: 106
Association of short-term exposure to ambient air pollutants with liver function and mediation by fasting insulin: evidence from a rural cohort in China
短期暴露于环境空气污染物与肝功能的关系及空腹胰岛素的中介作用：来自中国农村队列研究的证据
Mengxin WangAogang ZhangWeidong Wu
Research 23 January 2026
Article: 105
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
Adjuvant tislelizumab, lenvatinib, and capecitabine for resected biliary tract cancer: a prospective phase II trial
辅助治疗：替雷利珠单抗、仑伐替尼和卡培他滨用于可切除的胆道癌：一项前瞻性II期试验
Yun FengNing ZhangLu Wang
Research 23 January 2026
Article: 104
Comparative effectiveness of sleeve gastrectomy and semaglutide for weight loss and metabolic outcomes: a prospective non-randomized study
袖状胃切除术与司美格鲁肽对减重及代谢结局的疗效比较：一项前瞻性非随机研究
Yutung YenQian ZhangYi Chen
Research 22 January 2026
Article: 103
Part of 1 collection:Weight loss interventions and their health impacts
所属专题：减重干预措施及其对健康的影响
Impact of sex on outcomes in patients treated with drug-coated balloons versus drug-eluting stents for de novo coronary artery lesions: Insights from the REC-CAGEFREE I trial
性别对接受药物涂层球囊与药物洗脱支架治疗的新发冠状动脉病变患者预后的影响：来自REC-CAGEFREE I试验的见解
Ping WangJingyu ZhouLing Tao
Research 22 January 2026
Article: 102
Assessing the comorbidity between asthma and depression through polygenic risk scoring and time-to-event models
通过多基因风险评分和时间事件模型评估哮喘与抑郁的共病情况
Xueting WangJun HeRenato Polimanti
Research 22 January 2026
Article: 101
Persistent immune, coagulation and cardiac dysregulation are correlated with later post-discharge mortality in children with severe malnutrition
严重营养不良儿童出院后持续存在的免疫、凝血和心脏功能失调与后期死亡率相关
Brenda KamauEvans O. MudiboJames M. Njunge
Research 22 January 2026
Article: 100
Correction: Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022
更正：计算机辅助口头尸检：对比大型语言模型与医生为2019 - 2022年塞拉利昂6939例死亡分配病因的情况
Richard WenAnteneh Tesfaye AssalifRashid Ansumana
Correction 14 February 2026
Article: 99
Characteristics of parks associated with depression in women only: a cross-sectional study of 329,363 adults
仅与女性抑郁相关的公园特征：一项针对329,363名成年人的横断面研究
Jonathan R. OlsenNatalie NichollsRichard Mitchell
Research 21 January 2026
Article: 98
Weight change mediates the effect of lifestyle intervention on postpartum diabetes in women with prior gestational diabetes: a secondary analysis of a randomized clinical trial
在生活方式干预对既往妊娠期糖尿病女性产后糖尿病影响中，体重变化的中介作用：一项随机临床试验的二次分析
Weiqin LiHuikun LiuGang Hu
Research 21 January 2026
Article: 97
Part of 1 collection: Diagnosis and management of gestational diabetes
所属专题：妊娠期糖尿病的诊断与治疗
Global drivers of heart failure attributable to atrial fibrillation/flutter: insights fromJoinpoint regression, age-period-cohort analysis, and future projections from the GBD 2021 Study
心房颤动/扑动所致心力衰竭的全球驱动因素：来自折点回归、年龄-时期-队列分析以及2021年GBD（全球疾病负担）研究未来预测的见解
Jing ChenZhu LiGregory Y. H. Lip
Research 20 January 2026
Article: 96
Part of 1 collection: Cardiomyopathy and cardiac arrhythmias
所属专题：心肌病与心律失常
Overdiagnosis of gestational diabetes mellitus during Ramadan: a retrospective population-based study in Catalonia, Spain
斋月期间妊娠期糖尿病的过度诊断：西班牙加泰罗尼亚地区一项基于人群的回顾性研究
Marta CarrascoBogdan VlachoMarta Hernández
Research 20 January 2026
Article: 95
Part of 1 collection: Diagnosis and management of gestational diabetes
所属专题：妊娠期糖尿病的诊断与管理
Why current risk factor-based approaches fall short in predicting stillbirth: a national cohort study of nulliparous women in England
为何当前基于风险因素的方法在预测死胎方面存在不足：英格兰初产妇全国队列研究
A. HowellB. ThilaganathanTommy’s National Centre for Maternity Improvement
Research 22 January 2026
Article: 94
Pay-it-forward intervention increased pneumococcal vaccine uptake among older adults in China: a randomized controlled trial
爱心传递干预措施提高了中国老年人肺炎球菌疫苗的接种率：一项随机对照试验
Jiao QinChunxing TaoBingyu Liang
Research 19 January 2026
Article: 93
The impact of e-cigarette taxation: a systematic review and meta-analysis on usage, pricing strategies, and public health implications
电子烟税收的影响：针对使用情况、定价策略和公共卫生影响开展的系统综述和荟萃分析
Quan WangZheng ZhuLi Yang
Research 17 January 2026
Article: 92
Safety and preliminary efficacy results of IBI389, an anti-Claudin18.2×CD3 bispecific antibody, in patients with solid tumors and gastric or gastro-esophageal tumors: a phase 1 dose escalation and expansion study
抗Claudin18.2×CD3双特异性抗体IBI389在实体瘤及胃或胃食管肿瘤患者中的安全性与初步疗效结果：一项1期剂量递增与扩展研究
Xiaoyu LiRuihong DaiFeng Bi
Research 16 January 2026
Article: 91
Part of 1 collection: Clinical trials for gastrointestinal cancer
所属专题：胃肠道癌症临床试验
Comparative risk of delirium among opioid users for non-cancer pain: a retrospective cohort study
比较非癌症疼痛使用阿片类药物者发生谵妄的风险：一项回顾性队列研究
Carlos Raul Ramirez MedinaMark LuntMeghna Jani
Research 31 January 2026
Article: 90
Association between preoperative interruption of antiplatelet therapy and postoperative thrombotic risk after minimally invasive surgery for abdominopelvic cancer in patients treated with P2Y12 inhibitors
接受P2Y12抑制剂治疗的患者行腹部盆腔癌症微创手术时，术前中断抗血小板治疗与术后血栓形成风险之间的关联
Masashi KubotaSatomi YoshidaKoji Kawakami
Research 16 January 2026
Article: 89
Comparative outcomes of distal ureterectomy vs. radical nephroureterectomy in high-risk distal ureteral urothelial carcinoma: a two-center cohort study in Northern and Southern China
高危远端输尿管尿路上皮癌患者行远端输尿管切除术与根治性肾输尿管切除术的疗效比较：中国北方和南方两家中心的队列研究
Junyi XieZhenhua LiuWei Yu
Research 16 January 2026
Article: 88
Co-occurrence patterns and related risk factors of dementia and Parkinson’s disease among older adults across 204 countries and territories: a spatial correspondence and systematic analysis
204个国家和地区老年人痴呆症与帕金森病共现模式及相关危险因素：空间对应与系统分析
Weiyang ChenMin DuJue Liu
Research 15 January 2026
Article: 87
Accelerated brain aging in amyotrophic lateral sclerosis and its prognostic associations: a cohort study
肌萎缩侧索硬化症加速脑衰老及其预后关联：一项队列研究
Chenhao FangJiaoting JinShuoqiu Gan
Research 15 January 2026
Article: 86
Part of 1 collection: Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题：肌萎缩侧索硬化症：最新进展与新动态
The clinical effects and cortical mechanism of rTMS in poststroke lateropulsion: a randomized controlled trial
重复经颅磁刺激（rTMS）对脑卒中后侧方倾倒的临床效果及皮质机制：一项随机对照试验
Lijiao MengRaymond C. C. TsangQuan Wei
Research 14 January 2026
Article: 85
5-HT2C receptors in the glutamatergic neurons of dorsal raphe nucleus orchestrate the comorbidity of pain and anxiety in mice
中脑背侧缝际核谷氨酸能神经元中的5-HT2C受体调控小鼠疼痛与焦虑共病
Qi ZhangLi XieRiyue Jiang
Research 13 January 2026
Article: 84
The clinical landscape of POLE-mutant colorectal cancer: a retrospective analysis of real-world outcome
POLE突变型结直肠癌的临床现状：一项现实结局的回顾性分析
Ting XuXuhui ZhangJian Li
Research 13 January 2026
Article: 83
The efficacy and safety of duloxetine in treating refractory chronic cough: a randomized clinical trial
度洛西汀治疗难治性慢性咳嗽的有效性和安全性：一项随机临床试验
Shengyuan WangHeng WuXianghuai Xu
Research 13 January 2026
Article: 82
Impact of diagnosis to ablation time on clinical outcomes in patients with atrial fibrillation: post hoc analysis of the CABANA trial
心房颤动患者从诊断到消融的时间对临床预后的影响：CABANA试验的事后分析
Manlin ZhaoYang ChenGregory Y. H. Lip
Research 12 January 2026
Article: 81
Part of 1 collection: Cardiomyopathy and cardiac arrhythmias
所属专题：心肌病与心律失常
Elevated maternal pre-transfer serum lipid peroxidation is associated with implantation failure and early pregnancy loss
母体转运前血清脂质过氧化水平升高与着床失败和早期流产相关
Zhangwei JiaJunxiang RenJunhao Yan
Research 12 January 2026
Article: 80
Impact of Helicobacter pylori infection on gut and intratumoral microbiome and its association with immunotherapy response in gastrointestinal cancer
幽门螺杆菌感染对肠道和肿瘤内微生物组的影响及其与胃肠道癌症免疫治疗反应的关联
Keren JiaYang ChenLin Shen
Research 12 January 2026
Article: 79
Part of 1 collection: Gut microbiota: New treatments of human disease
所属专题：肠道微生物组：人类疾病的新疗法
SGLT-2 Inhibitor use and liver-related and mortality outcomes in patients with type 2 diabetes and compensated cirrhosis
SGLT-2抑制剂在2型糖尿病合并代偿性肝硬化患者中的应用及其对肝脏相关预后和死亡率的影响
Tien-Shin ChouDaniel Hsiang-Te TsaiEdward Chia-Cheng Lai
Research 12 January 2026
Article: 78
Extrapolating from trials to clinic: a predictive model defining the boundaries of benefit for multiple sclerosis therapies in real-world populations based on systematic review
从试验外推至临床：基于系统综述构建预测模型，界定多发性硬化症疗法在现实人群中的获益边界
Bibiana BielekovaTianxia WuMichael Calcagni
Research 10 January 2026
Article: 77
A validated model for early prediction of group A streptococcal aetiology in necrotising soft tissue infections using minimal patient data
利用最少患者数据早期预测坏死性软组织感染A组链球菌病因的验证模型
Sonja KatzJaco SuijkerEdoardo Saccenti
Research 10 January 2026
Article: 76
Trends in lipid-lowering therapies in acute coronary syndromes after Chinese new insurance policy: a real-world analysis
中国新医保政策实施后急性冠状动脉综合征患者降脂治疗趋势：一项现实情况分析
Xin ZhaoShujing WuJunbo Ge
Research 09 January 2026
Article: 75
Fragmented healthcare and effective maternal coverage in Mexico, 2009–2023
2009-2023年墨西哥医疗体系碎片化与有效孕产妇医疗保障
Edson Serván-MoriDiego Cerecero-GarcíaOctavio Gómez-Dantés
Research 09 January 2026
Article: 74
Circadian rhythm disruption in cardiovascular disease: a systematic review and meta-analysis of mechanistic evidence from animal models
昼夜节律紊乱与心血管疾病：基于动物模型机制证据的系统综述与荟萃分析
Mrinal K. DasEvi De RyckJohanna Samulin Erdem
Research 09 January 2026
Article: 73
Frailty progression: The role of multimorbidity configurations in frailty transitions and predicting mortality risk among older adults
衰弱进展：多重共病组合模式在老年人衰弱状态转变及死亡风险预测中的作用
Rafael Ogaz-GonzálezQian ZouEva Corpeleijn
Research 08 January 2026
Article: 72
Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学及风险因素的作用
Effect of probiotic supplementation on the gut microbiota diversity in healthy populations: a systematic review and meta-analysis of randomised controlled trials
益生菌补充剂对健康人群肠道微生物群多样性的影响：一项针对随机对照试验的系统综述和荟萃分析
Anna Júlia ÉliásKincső Csepke Földvári-NagyLászló Földvári-Nagy
Research 07 January 2026
Article: 71
Part of 1 collection: Gut microbiota: New treatments of human disease
所属专题：肠道微生物群：人类疾病的新疗法
Pain and high-impact pain in community-dwelling older adults in Australia and relation to sociodemographic and health-related factors, including physical disability, psychological distress, and quality of life
澳大利亚社区居住老年人的疼痛及重度疼痛情况，及其与社会人口统计学因素和健康相关因素（包括身体残疾、心理困扰和生活质量）的关系
Grace JoshySaman Khalatbari-SoltaniEmily Banks
Research 22 January 2026
Article: 70
Mortality and morbidity burden associated with smoking: evidence from a 1.6 million cohort in Hong Kong
与吸烟相关的死亡率和发病率负担：来自香港160万人队列研究的证据
Boyuan WangTingting ChenEric Yuk Fai Wan
Research 06 January 2026
Article: 69
Part of 1 collection:Carcinogens and human health
所属专题：致癌物与人类健康
Association between long-term extreme high temperature and mortality: a 9-million prospective cohort study
长期极端高温与死亡率之间的关系：一项900万人的前瞻性队列研究
Bo YinQi HuangKuiying Gu
Research 06 January 2026
Article: 68
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
Unraveling the neurotoxic mechanisms of tranexamic acid in epilepsy induction: a network toxicology and molecular docking approach
利用网络毒理学和分子对接方法揭示氨甲环酸诱发癫痫的神经毒性机制
Tianyang ChenDalong LiuXiangYang Leng
Research 03 January 2026
Article: 67
Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology
所属专题：癫痫：癫痫发作的预防、治疗和流行病学
Trop2 immuno-PET/CT imaging of prostate cancer: a proof-of-concept translational study
Trop2免疫正电子发射断层扫描/计算机断层扫描（PET/CT）成像在前列腺癌中的应用：一项概念验证性转化研究
Xingru LongShuxian AnDawei Jiang
Research 31 December 2025
Article: 66
Methylmalonate accumulation contributes to myocardial vulnerability post-reperfusion: a novel therapeutic target and prognostic biomarker
甲基丙二酸蓄积促进再灌注后心肌脆弱性：一种新型治疗靶点和预后生物标志物
Shanjie WangJunChen GuoShaohong Fang
Research 31 December 2025
Article: 65
Prophylactic effect of intraoperative sodium oxybate on postoperative delirium in older patients undergoing major orthopedic surgery: a randomized clinical trial
术中羟丁酸钠对接受大型骨科手术的老年患者术后谵妄的预防作用：一项随机临床试验
Meiying CuiHang XuePing Zhao
Research 31 December 2025
Article: 64
Part of 1 collection:Psychoactives: Recreational drugs repurposed as novel therapies
所属专题：精神活性物质：将娱乐性药物重新用于新型疗法
Prevalence of hysterectomy in urban China and associations between metabolic disorders and hysterectomy: a multicenter population-based study involving over 9 million women
中国城市子宫切除术的流行情况以及代谢紊乱与子宫切除术之间的关系：一项涉及超过900万女性的多中心人群基础研究
Yanrui BiYuan MaYing Gao
Research 30 December 2025
Article: 63
Sex differences in cardiac risk and kidney function: serum creatinine versus cystatin C
心脏风险和肾功能方面的性别差异：血清肌酐与胱抑素C的对比
Nicole L. De La MataJames A. HedleyJennifer S. Lees
Research 30 December 2025
Article: 62
The association of post-conization pregnancy with subsequent cervical lesions: evidence from a nationwide cohort in Sweden
锥切术后妊娠与后续宫颈病变的关联：来自瑞典全国队列研究的证据
Huan YiJimiao HuangJianguang Ji
Research 29 December 2025
Article: 61
Tibial periosteal distraction for ischemic leg ulcers: animal and clinical cohort study
胫骨骨膜牵张术治疗缺血性下肢溃疡：动物及临床队列研究
Peilin ZhouWenqiang WangQikai Hua
Research 28 December 2025
Article: 60
Preoperative conversion therapy of camrelizumab combined with paclitaxel and nedaplatin for unresectable advanced esophageal squamous cell carcinoma: a phase 2 study
卡瑞利珠单抗联合紫杉醇和奈达铂对不可切除的晚期食管鳞癌的术前转化治疗：一项2期研究
Jinhong ZhuJinfeng ZhangJianqun Ma
Research 28 December 2025
Article: 59
Clustering of cardiometabolic risk factors, physical activity, digital exclusion, and depressive symptoms trajectories in adults aged 50years and older: findings from two prospective cohort studies
50岁及以上成年人心血管代谢风险因素聚集、身体活动、数字排斥及抑郁症状轨迹：两项前瞻性队列研究的发现
Xiaosheng DongJiaqiang XiaoChengchao Zhou
Research 28 December 2025
Article: 58
Eligibility of real-world patients for aspirin primary prevention trials in cardiovascular disease
现实中符合心血管疾病阿司匹林一级预防试验资格的患者情况
Michael HolderDaniel R. MoralesBruce Guthrie
Research 27 January 2026
Article: 57
Polygenic risk score-guided personalized osteoporosis screening: a population-based study
基于多基因风险评分指导的个性化骨质疏松症筛查：一项基于人群的研究
Dongxue WangWen SunJianguang Ji
Research 14 January 2026
Article: 56
Urea cycle modulation by combined SGLT2 inhibitors and metformin
SGLT2抑制剂与二甲双胍联合用药对尿素循环的调节作用
Makoto HaradaJonathan AdamRui Wang-Sattler
Research 08 January 2026
Article: 55
Safety and neuroprotective efficacy of the VCP inhibitor ML240 in large-animal and human retinal explants: a preclinical ex vivo study
VCP抑制剂ML240在大型动物及人视网膜外植体中的安全性和神经保护功效：一项临床前离体研究
Ana-Cristina Almansa-GarcíaAngela ArmentoBlanca Arango-Gonzalez
Research 10 January 2026
Article: 54
Impact of an eight-week isocaloric vegan dietary intervention on hemogram parameters and lymphocyte subsets: a randomized-controlled trial
为期八周的等热量纯素饮食干预对血细胞参数和淋巴细胞亚群的影响：一项随机对照试验
Julian HerterFrieda StübingMaximilian Andreas Storz
Research 10 January 2026
Article: 53
Association between psychosocial factors and adverse effects of light-to-moderate ambient heat in patients with chronic diseases: results of the prospective cohort study CLIMATE-II
社会心理因素与轻至中度环境热对慢性病患者不良影响之间的关联：前瞻性队列研究CLIMATE-II的结果
Ingmar SchäferValentina PauckeDagmar Lühmann
Research 15 January 2026
Article: 52
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
Maternal infection during pregnancy and the risk of childhood cancer: a systematic review and meta-analysis
孕期母体感染与儿童期患癌风险：一项系统综述和荟萃分析
Loviisa MulanjeLara Kim BrackmannRajini Nagrani
Research 14 January 2026
Article: 51
Part of 1 collection:Carcinogens and human health
所属专题：致癌物与人类健康
Supplementary biomarker testing in molecular tumor boards increases actionable therapy recommendations: a prospective real-world study of 658 patients
分子肿瘤委员会中的补充生物标志物检测增加了可采取治疗措施的建议：一项针对658例患者的前瞻性真实世界研究
Alexander ScheiterSimon MellinKirsten Utpatel
Research 14 January 2026
Article: 50
Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022
计算机辅助口头尸检：对比大型语言模型与医生对塞拉利昂2019 - 2022年6939例死亡原因的判定
Richard WenAnteneh Tesfaye AssalifRashid Ansumana
Research 24 December 2025
Article: 49
Loss of Y chromosome and its implications in male amyotrophic lateral sclerosis: insights from the UK Biobank
Y染色体缺失及其在男性肌萎缩侧索硬化症中的影响：来自英国生物银行的研究见解
Wei-Ming SuQing-Qing DuanYong-Ping Chen
Research 24 December 2025
Article: 48
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题：肌萎缩侧索硬化症：最新进展与新动态
Prenatal lipopolysaccharide exposure programs the early-life lung development by modulating mesenchymal fibroblasts in a time- and dose-dependent manner
产前脂多糖暴露通过调节间充质成纤维细胞以时间和剂量依赖性方式来影响早期肺部发育
Ying DongStefan HadzicSaverio Bellusci
Research 22 December 2025
Article: 47
Life course socioeconomic trajectories and chronic disease risk in later life among 30,055 older adults across 27 European countries (the SHARE study)
27个欧洲国家30,055名老年人生命历程中的社会经济轨迹与晚年慢性疾病风险（基于SHARE研究）
Taymara C. AbreuJoline W. J. BeulensJoreintje D. Mackenbach
Research 20 December 2025
Article: 46
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学与风险因素的作用
Validation of a novel patient-reported measure of the burden of digital care in diabetes
由糖尿病患者报告的数字化护理负担新型测评工具的验证
Misk Al ZahidyJennifer L. RidgewayVictor M. Montori
Research 20 December 2025
Article: 45
Determinants of long-term SARS-CoV-2 immune responses in asymptomatic-to-moderate COVID-19 patients in sub-Saharan Africa
撒哈拉以南非洲地区无症状至中度 COVID-19 患者长期 SARS-CoV-2 免疫应答的决定因素
Víctor L. de RiojaOdin GoovaertsGemma Moncunill
Research 14 January 2026
Article: 44
Camrelizumab and apatinib in Chinese patients with locally advanced or metastatic radioiodine-refractory differentiated thyroid cancer: an exploratory open-label, single-arm trial
卡瑞利珠单抗联合阿帕替尼治疗中国局灶性晚期或转移性放射性碘难治性分化型甲状腺癌：一项探索性开放标签单臂试验
Xin ZhangDi SunYansong Lin
Research 18 December 2025
Article: 43
Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk: the PREDIMED trial
地中海饮食的尿液多酚特征与心血管疾病风险较低相关：PREDIMED 试验
Inés Domínguez-LópezPolina GalkinaRosa M. Lamuela-Raventós
Research 18 December 2025
Article: 42
Meta-analysis and external validation of a risk model for gastrointestinal bleeding after percutaneous coronary intervention
经皮冠状动脉介入治疗后胃肠道出血风险模型的荟萃分析及外部验证
Hualong MaCong PengQiaohong Yang
Research 18 December 2025
Article: 41
DNA methylation-based clocks, tobacco smoking, and lung cancer risk
基于DNA甲基化的生物钟、烟草吸烟与肺癌风险
Ricardo Cortez Cardoso PenhaJustina Ucheojor OnwukaMattias Johansson
Research 17 December 2025
Article: 40
Part of 1 collection:Carcinogens and human health
所属专题：致癌物与人类健康
Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70years old
认知功能未受损的70岁老年人基于人口的队列中，与大脑灰质模式相关的风险和保护因素
Giulia LorenzonAnna MarsegliaEric Westman
Research 17 December 2025
Article: 39
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学和风险因素的作用
Street view-derived city built environment and vulnerability to temperature extremes: a nationally representative population-based cohort study
基于街景图像的城市建成环境与极端温度脆弱性：一项全国代表性人口队列研究
Wanzhou WangChao YangLuxia Zhang
Research 16 December 2025
Article: 38
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
A booster dose of an inactivated SARS-CoV-2 vaccine targeting virus variants sustains protective humoral and cellular immunity
针对病毒变异株的灭活严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）疫苗加强针可维持保护性体液免疫和细胞免疫
Constanza MéndezLinmar Rodríguez-GuilarteSusan M. Bueno
Research 15 December 2025
Article: 37
Dapagliflozin alleviates sunitinib-induced cardiotoxicity through AMPKα-PPARα axis and enhances the sensitivity of renal cell carcinoma to sunitinib
达格列净通过AMPKα-PPARα轴减轻舒尼替尼诱导的心脏毒性，并增强肾细胞癌对舒尼替尼的敏感性
Shi-yu HuangMin HuLei Wang
Research 15 December 2025
Article: 36
Network dysfunction underlying verbal fluency deficits in newly diagnosed epilepsy: a resting-state fMRI functional connectivity study
新诊断癫痫患者言语流畅性缺陷背后的网络功能障碍：一项静息态功能磁共振成像功能连接研究
Fangzhou LiuPing JiangLing Liu
Research 13 December 2025
Article: 35
Part of 1 collection:Epilepsy: Seizure prevention, treatment, and epidemiology
所属专题：癫痫：癫痫发作的预防、治疗和流行病学
Long-term quality of life in non-epithelial ovarian cancer survivors: TMRG-GINECO-Vivrovaire rare tumors case–control study
基于广西新生儿地中海贫血基因组图谱计划开展的家庭三联体/四联体分析
Coraline DubotIsabelle Ray-CoquardFlorence Joly
Research 12 December 2025
Article: 34
Family trios/quartets analysis based on the Newborn Genomic Atlas for Thalassemia project in Guangxi
非上皮性卵巢癌幸存者的长期生活质量：TMRG-GINECO-Vivrovaire罕见肿瘤病例对照研究
Wei WeiChunrong GuiBaoheng Gui
Research 12 December 2025
Article: 33
Hyperuricemic persons use more analgesics than normouricemic—is asymptomatic hyperuricemia really asymptomatic?
高尿酸血症患者比血尿酸正常者使用更多镇痛药——无症状性高尿酸血症真的“无症状”吗？
Janis TimsansJenni Emilia KauppiMarkku Kauppi
Research 11 December 2025
Article: 32
Social isolation, loneliness, and multi-system medical conditions: phenome-wide association and disease-trajectory analyses
社会孤立、孤独感与多系统医学病症：全表型组关联分析及疾病轨迹研究
Tingshan DuanZhi CaoChenjie Xu
Research 10 December 2025
Article: 31
Digital marketing techniques within online food retail platforms: a scoping review
在线食品零售平台中的数字营销技巧：一项范围综述
Adyya GuptaCatherine E. HugginsAnna Peeters
Research 10 December 2025
Article: 30
Dramatic increases in redundant publications in the Generative AI era
生成式人工智能时代冗余出版物数量急剧增加
Danny MaupinTulsi SuchakMatt Spick
Research 09 December 2025
Article: 29
Cardiovascular risk burden and guideline-recommended lipid and blood pressure goals in an Italian Cohort: findings from the HUMTELEMED web-based platform
意大利人群心血管风险负担及指南推荐的血脂和血压目标达成情况：HUMTELEMED网络平台的发现
Matteo LandolfoAlessandro GezziRiccardo Sarzani
Research 09 December 2025
Article: 28
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学及风险因素的作用
Efficacy and safety of Janus kinase 1/2 inhibitor KL130008 in active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase II trial
Janus激酶1/2抑制剂KL130008治疗活动性类风湿关节炎的有效性和安全性：一项随机、双盲、安慰剂对照的II期试验
Yue ChengHonghu TangYi Liu
Research 09 December 2025
Article: 27
Risk stratification for endometrial cancer: independent and joint effects of polygenic risk score and body mass index in 129,829 UK Biobank participants
子宫内膜癌的风险分层：英国生物银行129,829名参与者中多基因风险评分和体重指数的独立及联合效应
Xuemin WangLaure DossusTracy A. O’Mara
Research 10 February 2026
Article: 26
Maternal probiotics intake during pregnancy and exclusive colostrum breastfeeding are associated with a reduced risk of neonatal jaundice
孕期摄入益生菌及纯母乳喂养初乳与新生儿黄疸风险降低相关
Bekalu Kassie AlemuChi Chiu WangYao Wang
Research 08 December 2025
Article: 25
Hepatic steatosis in postmenopausal women is characterized by distinct serum extracellular vesicle proteomic signatures
绝经后女性脂肪肝具有独特的血清细胞外囊泡蛋白质组特征
Patrick PirrotteBrooke LovellJohanna K. DiStefano
Research 07 December 2025
Article: 24
Global, regional, and national temporal trends in the prevalence of environmental heat and cold exposure among older adults aged 60–99 years, 1990–2021: an age-period-cohort analysis based on the Global Burden of Disease Study 2021
基于2021年全球疾病负担研究，对1990 - 2021年60 - 99岁老年人环境热暴露和冷暴露患病率的全球、区域和国家时间趋势分析：一项基于年龄 - 时期 - 队列模型的分析
Shenghao XuJing WangJianlin Xiao
Research 07 December 2025
Article: 23
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
Cyclophilin B deficiency enhances myocardial energy synthesis and protects against heart failure in preclinical models
亲环蛋白B缺乏可增强心肌能量合成，并在临床前模型中预防心力衰竭
Xiao ZongXierenayi TudiRong Tao
Research 07 December 2025
Article: 22
Part of 1 collection:Cardiomyopathy and cardiac arrhythmias
所属专题：心肌病与心律失常
Normobaric hyperoxia for intracerebral hemorrhage: a randomized clinical trial
常压高氧治疗脑出血：一项随机临床试验
Zhiying ChenJiayue DingRan Meng
Research 07 December 2025
Article: 21
Nationwide trends in pediatric hospitalizations for eating disorders in France between 2013 and 2022: a retrospective study using the national health insurance database
Emmanuelle LogeaisFrançoise TroussierLilia Khendek
2013 - 2022年法国因进食障碍住院的儿科患者全国趋势：一项使用国家健康保险数据库的回顾性研究
Research 05 December 2025
Article: 20
Part of 1 collection:Child and adolescent psychiatry
所属专题：儿童与青少年精神病学
Self-management of vaginal pessaries for pelvic organ prolapse: multi-method process evaluation, linked to the TOPSY randomised controlled trial
盆腔器官脱垂阴道子宫托自我管理：与TOPSY随机对照试验相关的多方法过程评估
Carol BuggeMelanie Dembinskythe TOPSY team
Research 05 December 2025
Article: 19
Large-scale plasma proteomics reveals bidirectional associations between sleep patterns and inflammatory bowel disease: a prospective cohort study
大规模血浆蛋白质组学研究揭示睡眠模式与炎症性肠病之间的双向关联：一项前瞻性队列研究
Kaixing LeYaru LiuZhigang Liu
Research 05 December 2025
Article: 18
Association between socioeconomic status and diabetic retinopathy in individuals with type 1 diabetes: a systematic review and meta-analysis
1型糖尿病患者社会经济地位与糖尿病视网膜病变之间的关联：一项系统综述和荟萃分析
Fernando Sebastian-VallesSergio Núñez de Arenas-ArroyoJulia Martínez-Alfonso
Review 05 December 2025
Article: 17
Patterns of disparity: age and socioeconomic differences in women’s smoking and quitting outcomes in Great Britain
差异模式：英国女性吸烟及戒烟结局的年龄和社会经济差异
Sarah E. JacksonCaitlin NotleySharon Cox
Research 10 February 2026
Article: 16
Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression
SWI/SNF复合体中的基因组致病性改变通过下调STING表达损害中国KRAS突变型非小细胞肺癌患者的免疫治疗效果
Lingling GaoJie JiangXuchao Zhang
Research 03 December 2025
Article: 15
Residential radon exposure and incident myocardial infarction and stroke risks in the All of Us Research Program
“我们所有人”研究项目中住宅氡暴露与心肌梗死和卒中发病风险的关系
Jiajun LuoZhihao JinBriseis Aschebrook-Kilfoy
Research 03 December 2025
Article: 14
Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet and cardiovascular disease and arrhythmias
用于延缓神经退行性变的地中海饮食-终止高血压膳食疗法干预措施（MIND）与心血管疾病及心律失常的关系
Pei QinFrederick K. HoJill P. Pell
Research02 December 2025
Article: 13
Part of 1 collection: Cardiomyopathy and cardiac arrhythmias
所属专题：心肌病与心律失常
KoMethylNet: a novel epigenetic clock based on neural network analysis of DNA methylation data and epigenetic age acceleration in a Korean population
KoMethylNet：基于神经网络分析DNA甲基化数据的新型表观遗传时钟及韩国人群的表观遗传年龄加速研究
Dabin YunKwangyeon OhNan Song
Research 03 December 2025
Article: 12
Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学及风险因素的作用
Sleep and physical activity trade-offs and dementia risk: a prospective cohort study in UK Biobank participants
睡眠与体力活动的权衡与痴呆风险：英国生物样本库参与者的一项前瞻性队列研究
Stephanie YiallourouLachlan CribbMatthew P. Pase
Research 03 December 2025
Article: 11
Part of 1 collection: Sleep and mental health
所属专题：睡眠与心理健康
Integration of gut microbiome and lipid metabolism reveals the anti-cancer effects of pentadecanoic acid on bladder cancer
肠道微生物组与脂质代谢的整合揭示十五烷酸对膀胱癌的抗癌作用
Ya-Ting ChenJing SuiEvan Yi-Wen Yu
Research 03 December 2025
Article: 10
Part of 1 collection: Gut microbiota: New treatments of human disease
所属专题：肠道微生物群：人类疾病的新疗法
A social determinants-based county-level cardiovascular mortality index to identify high-risk counties in the USA
基于社会决定因素的美国县级心血管疾病死亡率指数，用于识别高风险县
Anqi ZhuBibhas ChakrabortyTazeen H. Jafar
Research 02 December 2025
Article: 9
HIV infection and immunosenescence: challenges and intervention strategies
HIV感染与免疫衰老：挑战与干预策略
Junyan JinQianqian XuBin Su
Review 02 December 2025
Article: 8
Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学与风险因素的作用
Machine learning-based prediction of short-term outcomes in aneurysmal subarachnoid hemorrhage: a multicenter study integrating clinical and inflammatory indicators
基于机器学习的动脉瘤性蛛网膜下腔出血短期预后预测：一项整合临床与炎症指标的多中心研究
Weichong ZhouCong PengHui Shi
Research 29 November 2025
Article: 7
The effectiveness and safety of a mobile application-based self-regulation intervention to support weight loss among adults living with obesity: a large-scale pragmatic randomised controlled trial
基于移动应用程序的自我调节干预措施在支持肥胖成年人减重方面的有效性与安全性：一项大规模实用性随机对照试验
Paul DoodyGina M. WrenPaul Aveyard
Research 29 November 2025
Article: 6
Part of 1 collection: Weight loss interventions and their health impacts
所属专题：减重干预措施及其对健康的影响
Adiposity and the first-onset of diagnosed mental illnesses: a population-based cohort study of 10 million UK adults
脂肪堆积（肥胖程度）与首次确诊精神疾病的关系：一项基于1000万英国成年人的队列研究
Xue DongPaul AveyardMin Gao
Research 29 November 2025
Article: 5
Efficacy of standard care versus acoustic therapy on acute tinnitus in idiopathic sudden sensorineural hearing loss: a randomized controlled trial
标准治疗与声治疗对特发性突发性感音神经性听力损失伴急性耳鸣的疗效对比：一项随机对照试验
Xinyi WangKe QiuYu Zhao
Research 28 November 2025
Article: 4
Trends and socio-economic inequalities in overweight- and obesity-related premature cardiovascular disease mortality in Australia
澳大利亚超重与肥胖相关过早心血管疾病死亡的趋势及社会经济不平等状况
Tim Adair
Research 29 January 2026
Article: 3
Assessing the impact of maternal blood pressure during pregnancy on perinatal health: a wide-angled Mendelian randomization study
评估孕期母体血压对围产期健康的影响：一项广角孟德尔随机化研究
Fernanda Morales-BersteinAna Gonçalves-SoaresMaria-Carolina Borges
Research 14 January 2026
Article: 2
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题：妊娠期糖尿病的诊断与管理
Prevalence of use and interest in using glucagon-like peptide-1 receptor agonists for weight loss: a population study in Great Britain
胰高血糖素样肽-1受体激动剂用于减重的使用率及使用意愿：一项针对英国人群的研究
Sarah E. JacksonJamie BrownLion Shahab
Research 08 January 2026
Article: 1
Part of 1 collection: Weight loss interventions and their health impacts
所属专题：减重干预措施及其对健康的影响
2026-07-20
编者按：2026年欧洲肿瘤内科学会（ESMO）年会将于10月23日~27日在西班牙马德里召开。作为全球肿瘤学领域最具影响力的学术盛会之一，ESMO每年吸引数万名国际顶尖学者，通过"线上+线下"相结合的模式，搭建起跨国界、跨学科的深度交流平台。目前，ESMO官网已公布口头报告标题（LBA尚未公布）及壁报标题。在血液肿瘤领域，今年共有26余项中国研究成功入选，其中包括3项口头报告、多篇Poster（正式壁报） 及多篇ePoster（电子壁报） ，涵盖多发性骨髓瘤、慢性淋巴细胞白血病/小淋巴细胞淋巴瘤、急性髓系白血病、弥漫大B细胞淋巴瘤、套细胞淋巴瘤、边缘区淋巴瘤、外周T细胞淋巴瘤、伯基特淋巴瘤、原发中枢神经系统淋巴瘤、霍奇金淋巴瘤等多个亚型，涌现出双特异性抗体、第四代BTK抑制剂、抗体偶联药物（ADC）、快速制备CAR-T、蛋白降解靶向嵌合体（PROTAC）及机器学习预测模型等前沿方向，充分彰显了中国在血液肿瘤原创药物与临床研究领域的快速崛起与引领潜力。《肿瘤瞭望-血液时讯》特别整理相关内容，以供参考（如有遗漏或错误，欢迎留言指正）。
口头报告（Oral）
摘要号：1456O
英文标题：A first-in-human phase I study of LBL-034, a GPRC5D/CD3 bispecific antibody, in relapsed/refractory multiple myeloma (RRMM)
中文标题：GPRC5D/CD3双特异性抗体LBL-034用于复发/难治性多发性骨髓瘤的首次人体I期临床研究
讲者：窦雪琳教授单位：北京大学人民医院 血液科
摘要号：1457O
英文标题：First Report of a Phase Ib Study of Rocbrutinib, a Fourth-Generation Bruton's Tyrosine Kinase Inhibitor, Combined with R-CHOP in Patients with Previously Untreated B-Cell Lymphoma
中文标题：第四代BTK抑制剂洛布替尼联合R-CHOP方案治疗初治B细胞淋巴瘤患者的Ib期临床研究首次报道
讲者：蔡清清教授单位：中山大学肿瘤防治中心 淋巴瘤中心
摘要号：1458O
英文标题：Safety and Efficacy of TRS005, a Novel Anti-CD20 Antibody-Drug Conjugate, in Patients with Transformed Diffuse Large B-Cell Lymphoma: Results from a Phase I Study
中文标题：新型抗CD20抗体偶联药物（ADC）TRS005用于转化型弥漫大B细胞淋巴瘤患者的安全性与疗效：一项Ⅰ期临床研究结果
讲者：石远凯教授单位：中国医学科学院肿瘤医院
弥漫大B细胞淋巴瘤
摘要号：1475P
英文标题：Clinical, genetic, and immune microenvironmental landscapes of primary breast diffuse large B-cell lymphoma: a comparative study with nodal and immune-privileged site DLBCL
中文标题：原发性乳腺弥漫大B细胞淋巴瘤的临床、遗传及免疫微环境特征：与结内及免疫豁免部位DLBCL的比较研究
讲者：贾俊磊教授单位：天津医科大学肿瘤医院 淋巴瘤内科
边缘区淋巴瘤
摘要号：1465P
英文标题：A Phase II Trial of Orelabrutinib Combined with New CD20 Monoclonal Antibody in Previously Untreated Marginal Zone Lymphoma: A Multicenter, Single-Arm Study (ZOOM Trial) Results Update
中文标题：奥布替尼联合新型CD20单抗一线治疗边缘区淋巴瘤的II期多中心单臂研究（ZOOM试验）结果更新
讲者：李志铭教授单位：中山大学肿瘤防治中心
外周T细胞淋巴瘤
摘要号：1464P
英文标题：A Phase II Clinical Study of Liposomal Mitoxantrone Combined with Azacitidine in Relapsed/Refractory Angioimmunoblastic T-Cell Lymphoma
中文标题：脂质体米托蒽醌联合阿扎胞苷治疗复发/难治性血管免疫母细胞性T细胞淋巴瘤的II期临床研究
讲者：吴辉菁教授单位或地区：湖北省肿瘤医院
摘要号：1466P
英文标题：Mitoxantrone Hydrochloride Liposome Combined with COEP (CMOEP) as First-Line Therapy for Peripheral T-Cell Lymphoma: Interim Results of the Phase II COMPASS Trial
中文标题：盐酸米托蒽醌脂质体联合COEP方案（CMOEP）一线治疗外周T细胞淋巴瘤：II期COMPASS试验中期结果
讲者：Jingwei Yu单位或地区：天津
套细胞淋巴瘤
摘要号：1467P
英文标题：Orelabrutinib, Lenalidomide, and Rituximab as Frontline Therapy for Mantle Cell Lymphoma: Results of the Phase II POLARIS Study
中文标题：奥布替尼、来那度胺联合利妥昔单抗一线治疗套细胞淋巴瘤：II期POLARIS研究结果
讲者：宋拯教授单位或地区：天津医科大学肿瘤医院
摘要号：1487P
英文标题：Proteolysis-targeting chimera (PROTAC) targeting Bruton tyrosine kinase (BTK) degradation in mantle cell lymphoma
中文标题：靶向BTK降解的蛋白降解靶向嵌合体（PROTAC）在套细胞淋巴瘤中的应用
讲者：王晓晖教授单位或地区：天津医科大学肿瘤医院
转化型滤泡性淋巴瘤
摘要号：1490P
英文标题：Single-cell analysis and functional profiling reveal Galectin-3–driven reprogramming of the tumor immune microenvironment in transformed follicular lymphoma
中文标题：单细胞分析与功能研究揭示Galectin-3驱动转化型滤泡性淋巴瘤肿瘤免疫微环境重编程
讲者：贾俊磊教授单位：天津医科大学肿瘤医院 淋巴瘤内科
原发中枢神经系统淋巴瘤（BTK抑制剂真实世界研究）
摘要号：1496P
英文标题：Real-world studies on the efficacy and safety of Bruton's tyrosine kinase inhibitors in the treatment of primary central nervous system lymphoma
中文标题：布鲁顿酪氨酸激酶抑制剂治疗原发中枢神经系统淋巴瘤的真实世界疗效与安全性研究
讲者：Tiange Lu单位或地区：济南
伯基特淋巴瘤
摘要号：1497P
英文标题："Dual-Switch" Sequential CAR-T Therapy Overcomes Resistance in Relapsed/Refractory Burkitt Lymphoma: Clinical Efficacy and Cellular Kinetics
中文标题："双开关"序贯CAR-T疗法克服复发/难治性伯基特淋巴瘤耐药：临床疗效与细胞动力学
讲者：苏国爱教授单位或地区：北京高博博仁医院
B细胞恶性肿瘤（CAR-T）
摘要号：1499P
英文标题：Updated Safety and Efficacy of Fast-In-Time (FIT) anti-CD19 CAR T——A Non-Viral, 2-day Rapid Manufacture CAR T-cell Therapy in B-Cell Malignancies
中文标题：快速制备型抗CD19 CAR-T（FIT平台）——一种非病毒载体、2天快速制备的CAR-T细胞疗法在B细胞恶性肿瘤中的最新安全性与疗效更新
讲者：李萍教授单位：同济大学附属同济医院 血液内科
T细胞淋巴瘤（表观遗传调控与免疫治疗）
摘要号：1460P
英文标题：Chidamide-Mediated Epigenetic Reprogramming Improves the Anti-Lymphoma Efficacy of Allogeneic CAR-γδT Cells
中文标题：西达本胺介导的表观遗传重编程提高异体CAR-γδT细胞抗淋巴瘤疗效
讲者：Jiayi Han单位或地区：天津
淋巴瘤患者生存随访（护理/心理）
摘要号：CN66
英文标题：A study on latent classes and influencing factors of fear of disease progression in lymphoma patients during the survival follow-up period
中文标题：淋巴瘤患者生存随访期疾病进展恐惧的潜在类别及影响因素研究
讲者：Li N. Feng单位或地区：天津
电子壁报（ePoster）
慢性淋巴细胞白血病/小淋巴细胞淋巴瘤
摘要号：1502eP
英文标题：Predicting Bruton's Tyrosine Kinase Inhibitors Therapy Failure in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Using Machine Learning
中文标题：基于机器学习预测慢性淋巴细胞白血病/小淋巴细胞淋巴瘤患者布鲁顿酪氨酸激酶抑制剂治疗失败
讲者：Yutang Li单位或地区：青岛
摘要号：1506eP
英文标题：Sustained Benefit of Orelabrutinib in Relapsed/Refractory Chronic Lymphocytic Leukemia: Up to 5 Years of Follow-Up from a Phase 2 Study
中文标题：奥布替尼在复发/难治性慢性淋巴细胞白血病中的持续获益：一项II期研究长达5年的随访结果
讲者：徐卫 教授单位或地区：南京医科大学第一附属医院
急性髓系白血病
摘要号：1505eP
英文标题：Exosomal circRNF220 Engages ACLY to Drive AML Progression via Metabolic-Epigenetic Programming of M2 Macrophages and CD47-Dependent Immune Evasion
中文标题：外泌体circRNF220通过代谢-表观遗传重编程M2巨噬细胞及CD47依赖性免疫逃逸驱动急性髓系白血病进展
讲者：Hanyang Wu单位或地区：济南
侵袭性B细胞淋巴瘤
摘要号：4574eP
英文标题：Indindione-based drugs target USP8 to promote SLC7A11 ubiquitination and degradation, selectively inducing ferroptosis in TP53R175H-mutant aggressive B-Cell lymphoma
中文标题： 基于茚二酮类化合物靶向USP8促进SLC7A11泛素化降解，选择性诱导TP53R175H突变型侵袭性B细胞淋巴瘤铁死亡
讲者：Wenhua Wang单位或地区：天津
原发中枢神经系统淋巴瘤
摘要号：764eP
英文标题：Development and Internal Validation of a Dynamic Prognostic Nomogram for Primary Central Nervous System Lymphoma
中文标题：原发中枢神经系统淋巴瘤动态预后列线图的构建与内部验证
讲者：Zhicheng Chai单位或地区：漯河
弥漫大B细胞淋巴瘤
摘要号：1511eP
英文标题：Real-World Efficacy and Safety of Zuberitamab-Based Regimens in Previously Untreated Diffuse Large B-Cell Lymphoma: A Retrospective Single-Center Study
中文标题：基于泽贝妥单抗方案在初治弥漫大B细胞淋巴瘤中的真实世界疗效与安全性：一项回顾性单中心研究
讲者：Hanguo Guo单位或地区：广州
摘要号：1528eP
英文标题：Real-world efficacy and safety of glofitomab-based regimens in diffuse large B-cell lymphoma
中文标题：基于格菲妥单抗的方案在弥漫大B细胞淋巴瘤中的真实世界疗效与安全性
讲者：Liufang Gu单位或地区：西安
非霍奇金淋巴瘤（支持治疗）
摘要号：4034eP
英文标题：Telpegfilgrastim in Elderly Patients with Non-Hodgkin Lymphoma for Primary Prophylaxis of Chemotherapy-Induced Neutropenia: A Prospective Study
中文标题：拓培非格司亭在老年非霍奇金淋巴瘤患者中用于化疗所致中性粒细胞减少一级预防的前瞻性研究
讲者：Hongming He单位或地区：福州
摘要号：4051eP
英文标题：Efficacy and Safety of Telpegfilgrastim for Preventing Chemotherapy-Induced Neutropenia in Patients with Hematological Malignancies at Intermediate-to-High Risk of Febrile Neutropenia: A Prospective Real-World Study
中文标题： 拓培非格司亭预防中高危发热性中性粒细胞减少症血液肿瘤患者化疗所致中性粒细胞减少的疗效与安全性：一项前瞻性真实世界研究
讲者：Xushu Zhong单位或地区：成都
经典霍奇金淋巴瘤
摘要号：1531eP
英文标题： Clinical features and outcomes of secondary and primary extranodal classical Hodgkin lymphoma
中文标题：继发性与原发性结外经典霍奇金淋巴瘤的临床特征及预后
讲者：Jiayi Han单位或地区：天津
边缘区淋巴瘤
摘要号：1515eP
英文标题：Orelabrutinib plus Rituximab Maintenance after Short-Course Chemoimmunotherapy in Intermediate/High-Risk Marginal Zone Lymphoma
中文标题：奥布替尼联合利妥昔单抗维持治疗中高危边缘区淋巴瘤短程化学免疫治疗后
讲者：Zhilin Gao单位或地区：太原
更多壁报及LBA详情，敬请关注ESMO 2026大会后续报道。《肿瘤瞭望-血液时讯》将持续带来现场前沿动态，敬请期待。
（来源：《肿瘤瞭望–血液时讯》编辑部）
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100 项与 盐酸米托蒽醌脂质体 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 外周T细胞淋巴瘤 | 中国 | 2021-06-01 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 骨髓增生异常综合征 | 临床3期 | - | 2026-07-30 | |
| 治疗相关性急性髓系白血病 | 临床3期 | - | 2026-07-30 | |
| 急性髓性白血病 | 临床3期 | 中国 | 2026-03-10 | |
| 鼻咽癌 | 临床3期 | 中国 | 2023-02-15 | |
| 复发性鼻咽癌 | 临床3期 | - | 2023-02-01 | |
| 难治性外周T细胞淋巴瘤 | 临床3期 | 中国 | 2021-04-14 | |
| 鼻咽肿瘤 | 临床2期 | - | 2025-04-01 | |
| 髓系肿瘤 | 临床2期 | 中国 | 2024-02-29 | |
| 难治性弥漫性大 B 细胞淋巴瘤 | 临床2期 | 中国 | 2023-07-27 | |
| 视神经脊髓炎 | 临床2期 | 中国 | 2022-11-17 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床2期 | 32 | Liposomal mitoxantrone (Lipo-MIT) + PD-1 inhibitors | 廠網艱醖醖憲艱遞壓簾(鏇淵製願鏇淵艱夢製鹽) = 糧淵構鏇鬱鏇憲窪蓋構 繭夢衊範襯窪艱鬱觸衊 (簾醖憲築壓衊膚顧簾廠, 24.2 ~ 59.2) 更多 | 积极 | 2026-05-29 | ||
N/A | 24 | CMOP regimen | 構衊網繭襯齋齋鏇獵壓(壓選淵鹹構艱廠鬱鹽憲) = 46.2% versus 72.7% of patients 艱淵獵鏇繭淵窪獵鬱憲 (鏇範鏇夢齋壓觸獵淵製 ) 更多 | 积极 | 2026-05-12 | ||
Anthracycline-based regimens (CHOP or CHOP-like) | |||||||
N/A | 29 | Liposomal mitoxantrone (L-MIT) (20mg/m2) (Relapsed/Refractory Lymphoma) | 簾齋醖簾艱淵觸淵壓憲(壓鑰壓襯鹽構願鏇鏇鑰) = 襯繭蓋壓範衊襯蓋壓憲 鹹觸襯壓構蓋醖蓋繭壓 (構築蓋衊築鹽選蓋窪艱 ) 更多 | 不佳 | 2026-05-12 | ||
N/A | 23 | 醖襯鑰願製鹹願艱鬱鏇(鹽鏇衊淵簾蓋憲築獵壓) = Grade ≥3 neutropenia occurred in 56.5% of patients, and Grade ≥3 thrombocytopenia in 47.8%. Pulmonary infection was reported in 56.5% of patients (including 3 patients with pre-existing infection prior to treatment), and CMV reactivation occurred in 30.4% of patients, all of which resolved with supportive care. 廠襯艱觸築壓鹽鹽襯遞 (襯製鹹築窪簾繭鹽構衊 ) 更多 | 积极 | 2026-05-12 | |||
(NKTCL) | |||||||
N/A | 18 | 網鹽齋鹽鏇顧淵艱積膚(蓋遞淵簾構網蓋廠觸醖) = 膚選網獵齋範鹽衊衊獵 顧鬱積築簾淵衊蓋憲餘 (鏇鹽選顧蓋築簾蓋廠壓 ) 更多 | 积极 | 2026-05-12 | |||
(newly diagnosed HLH) | 網鹽齋鹽鏇顧淵艱積膚(蓋遞淵簾構網蓋廠觸醖) = 醖鹽窪鏇選鹽獵範顧願 顧鬱積築簾淵衊蓋憲餘 (鏇鹽選顧蓋築簾蓋廠壓 ) 更多 | ||||||
临床2期 | 13 | 繭窪襯衊簾築簾襯積鹽(膚蓋範齋壓憲築獵窪鹹) = 選構鏇簾淵鏇鹽衊廠繭 願獵廠鑰顧範顧糧齋壓 (顧鹽網襯範範憲鏇夢範 ) 更多 | 积极 | 2026-05-12 | |||
临床2期 | 35 | 餘積襯獵醖糧網艱鹽襯(衊餘選築構獵窪憲膚願) = 憲鬱積糧廠製獵夢鏇膚 壓範窪鑰鬱憲範簾鹹繭 (齋選齋鹽鹹鹽壓獵遞觸 ) 更多 | 积极 | 2026-05-12 | |||
(de novo AML) | 餘積襯獵醖糧網艱鹽襯(衊餘選築構獵窪憲膚願) = 齋觸夢窪鬱憲鏇繭鑰齋 壓範窪鑰鬱憲範簾鹹繭 (齋選齋鹽鹹鹽壓獵遞觸 ) | ||||||
N/A | 23 | 鬱窪廠夢襯糧夢襯願醖(網簾齋憲夢繭簾壓蓋願) = 膚觸繭醖選製艱鹹衊願 網窪蓋壓鹽蓋膚蓋鹽積 (繭蓋築醖廠夢膚醖鹽築 ) 更多 | 积极 | 2026-05-12 | |||
N/A | 28 | Liposomal Mitoxantrone intensified busulfan-based conditioning regimens | 淵齋選糧壓鹽構選觸醖(顧膚製衊窪壓獵糧壓夢) = 醖鬱憲遞膚衊顧餘壓選 憲網鬱構構糧憲鏇淵壓 (製餘獵鏇糧襯願餘鹹構 ) 更多 | 积极 | 2026-03-22 | ||
临床2期 | 外周T细胞淋巴瘤 一线 | 20 | Mitoxantrone Liposome + Chemotherapy | 簾獵壓齋鬱遞齋觸鬱鬱(廠壓觸齋憲壓製範積蓋) = 鹹願糧遞窪壓鬱網範鹽 醖獵鑰積鏇積範鬱夢鏇 (餘鬱願夢積夢襯夢簾鏇 ) 更多 | 积极 | 2025-12-24 |
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